Results 81 to 90 of about 156,533 (274)

Efficacy of intensity-modulated radiotherapy combined with chemotherapy or surgery in locally advanced squamous cell carcinoma of the head-and-neck

Biologics: Targets & Therapy, 2013
Hua Yang,* Li-Qiong Diao,* Mei Shi, Rui Ma, Jian-Hua Wang, Jian-Ping Li, Feng Xiao, Ying Xue, Man Xu, Bin ZhouDepartment of Radiotherapy Oncology, Xijing Hospital, Fourth Military Medical University, Xi'an, People's Republic of China*These ...
Yang H, Diao LQ, Shi M, Ma R, Wang JH, Li JP, Xiao F, Xue Y, Xu M, Zhou B   +9 more
doaj  

Impact of Treatment Technique on Testicular Dose and Sexual Activity in Rectal Cancer Patients

Brazilian Journal of Oncology
Objective To estimate the incidental radiation dose delivered to the testicles in three-dimensional conformal radiotherapy (3DCRT), intensity-modulated radiotherapy (IMRT), and volumetric-modulated arc therapy (VMAT) in rectal cancer patients ...
Poornachandra Tejaswi-Siddappa, Shamsundar Sunkappa, Jagannath Kunigal-Puttaswamy, Aradhana Katke, Nanda Ramanand, Thejaswini Boraiah   +5 more
doaj   +1 more source

Bayesian Adaptive Randomization Trial of Passive Scattering Proton Therapy and Intensity-Modulated Photon Radiotherapy for Locally Advanced Non-Small-Cell Lung Cancer.

Journal of Clinical Oncology, 2018
Purpose This randomized trial compared outcomes of passive scattering proton therapy (PSPT) versus intensity-modulated (photon) radiotherapy (IMRT), both with concurrent chemotherapy, for inoperable non-small-cell lung cancer (NSCLC).
Z. Liao, J. J. Lee, R. Komaki, Daniel R. Gomez, Michael S. O’Reilly, F. Fossella, G. Blumenschein, J. Heymach, A. Vaporciyan, S. Swisher, P. Allen, Noah Chan Choi, Thomas F. DeLaney, Stephen M. Hahn, James D. Cox, Charles S. Lu, R. Mohan   +16 more
semanticscholar   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Management of Chemotherapy for Stage II Nasopharyngeal Carcinoma in the Intensity-Modulated Radiotherapy Era: A Review

Cancer Management and Research, 2020
Peng Wu,* Yumei Zhao,* Li Xiang, Linglin Yang Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Linglin ...
Wu P, Zhao Y, Xiang L, Yang L
doaj  

Comparison of simple and complex liver intensity modulated radiotherapy

Radiation Oncology, 2010
Background Intensity-modulated radiotherapy (IMRT) may allow improvement in plan quality for treatment of liver cancer, however increasing radiation modulation complexity can lead to increased uncertainties and requirements for quality assurance.
Eccles Cynthia L, Purdie Thomas G, Lee Mark T, Sharpe Michael B, Dawson Laura A   +4 more
doaj   +1 more source

Left breast irradiation with tangential intensity modulated radiotherapy (t-IMRT) versus tangential volumetric modulated arc therapy (t-VMAT): trade-offs between secondary cancer induction risk and optimal target coverage

Radiation Oncology, 2019
Adjuvant radiotherapy is the standard treatment after breast-conserving surgery. According to meta-analyses, adjuvant 3d-conventional irradiation reduces the risk of local recurrence and thereby improves long-term survival by 5–10%.
Daniel Karpf, Mazen Sakka, M. Metzger, G. Grabenbauer   +3 more
semanticscholar   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Implementation of Aperture-Based Complexity Metrics of MLC Opening based on the IMRT Technique for Central Nervous System (CNS) and Breast cases [PDF]

Iranian Journal of Medical Physics
Introduction: Complexity metrics have been suggested to characterize treatment plans based on machine parameters such as multileaf collimator (MLC) position.
Meirisa Ambalinggi, Aloysius Putranto, Dewa Prasada, Ida Ayu Gayatri, Supriyanto Pawiro, Dwi Seno Kuncoro Sihono   +5 more
doaj   +1 more source

Fluence-map generation for prostate intensity-modulated radiotherapy planning using a deep-neural-network

Scientific Reports, 2019
A deep-neural-network (DNN) was successfully used to predict clinically-acceptable dose distributions from organ contours for intensity-modulated radiotherapy (IMRT).
Hoyeon Lee, Hojin Kim, J. Kwak, Young Seok Kim, S. W. Lee, Seungryong Cho, B. Cho   +6 more
semanticscholar   +1 more source