Results 61 to 70 of about 53,742 (305)

Intensity‐modulated radiotherapy for head and neck surgeons [PDF]

Head & Neck, 2015
AbstractThe development of intensity‐modulated radiotherapy (IMRT) has played a major role in improving outcomes and decreasing morbidity in patients with head and neck cancer. This review addresses this vital modality with a focus on the important role of the head and neck surgeon.
Stanley I, Gutiontov, Edward J, Shin, Benjamin, Lok, Nancy Y, Lee, Ruben, Cabanillas   +4 more
openaire   +2 more sources

Improved treatment outcome and lower skin toxicity with intensity-modulated radiotherapy vs. 3D conventional radiotherapy in anal cancer [PDF]

, 2020
PURPOSE Radiochemotherapy is the standard treatment for anal carcinoma (ACa). Intensity-modulated radiotherapy (IMRT) has been introduced, allowing focused irradiation of the tumor area. Whether physical benefits of IMRT translate to clinical benefits
Heinrich, Henriette, Misselwitz, Benjamin, Rogler, Gerhard, Kranzbühler, Helmut, Bütikofer, Simon, Sauter, Matthias, Sauter, Matthias; https://orcid.org/, Lombriser, Norbert, Keilholz, Georg, Vavricka, Stephan R   +9 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Intensity-modulated radiotherapy (IMRT) versus three-dimensional conformal radiotherapy (3DCRT) as treatment plans for head and neck tumours

Journal of the Pakistan Medical Association
Objectives: To compare intensity-modulated radiation therapy with three-dimensional conformal radiation therapy 3DCRTwith respect to dose coverage for target volume.
Abd Al-Taj Abd Ali Khaleel, Siham Sabah Abdullah, Sabbar Shukri Al-Bayaty, Nabaa Mohammad Ali Alazawy, Abdulrahman Mohammed Abdulbaqi   +4 more
doaj   +1 more source

Automation in intensity-modulated radiotherapy treatment planning - a review of recent innovations

, 2018
Radiotherapy treatment planning of complex radiotherapy techniques, such as Intensity Modulated Radiotherapy (IMRT) and Volumetric Modulated Arc Therapy (VMAT), is a resource-intensive process requiring a high level of treatment planner intervention to ...
Verellen, Dirk, Heijmen, Ben, Hussein, Mohammad, Nisbet, A, Verellen, D, Hussein, M, Heijmen, Ben J M, Nisbet, Andrew   +7 more
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Three-dimensional conformal radiotherapy, static intensity-modulated and helical intensity-modulated radiotherapy in glioblastoma. Dosimetric comparison in patients with overlap between target volumes and organs at risk.

, 2014
Aims and background. Radiotherapy is the standard treatment of glioblastoma. Three-dimensional conformal radiotherapy is the standard technique to treat glioblastoma.
Saiani, Federica, Borghetti, Paolo, Spiazzi Luigi, BUGLIONE DI MONALE E BASTIA, Michela, Triggiani, Luca, Lazzari, Barbara, Costa, Loredana, Shehi, Blerina, MAGRINI, Stefano Maria, Pedretti, Sara, PANCIANI, PIER PAOLO, Pasinetti, Nadia, Uccelli, Chiara, Donadoni, Laura   +13 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Retrospective evaluation of dosimetric quality for prostate carcinomas treated with 3D conformal, intensity-modulated and volumetric-modulated arc radiotherapy

, 2013
Introduction\ud \ud This study examines and compares the dosimetric quality of radiotherapy treatment plans for prostate carcinoma across a cohort of 163 patients treated across 5 centres: 83 treated with three-dimensional conformal radiotherapy (3DCRT),
Knight, Richard, Christie, David, Crowe, Scott B., Christie, David R. H., Trapp, Jamie, Kairn, Tanya, Kenny, John, Knight, Richard T., Trapp, Jamie V., Crowe, Scott, Middlebrook, Nigel, Hill, Brendan, Langton, Christian M.   +12 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source