Results 81 to 90 of about 53,742 (305)

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Forward-planned intensity modulated radiation therapy using a cobalt source: A dosimetric study in breast cancer

Journal of Medical Physics, 2013
This analysis evaluates the feasibility and dosimetric results of a simplified intensity-modulated radiotherapy (IMRT) treatment using a cobalt-therapy unit for post-operative breast cancer. Fourteen patients were included.
Savino Cilla, Joseph Kigula-Mugambe, Cinzia Digesù, Gabriella Macchia, Solomon Bogale, Mariangela Massaccesi, David Dawotola, Francesco Deodato, Milly Buwenge, Luciana Caravatta, Angelo Piermattei, Vincenzo Valentini, Alessio G Morganti   +12 more
doaj   +1 more source

Good tolerance and long-term complete remission after definitive intensity-modulated radiotherapy for locally advanced head and neck cancer in a patient with human immunodeficiency virus infection: A case report and literature review

, 2017
Background. The main concerns with radiation therapy for head and neck cancer in human immunodeficiency virus (HIV)-infected patients include limited tumor response and profound mucosal or skin toxicities under severe immunocompromised status.
Chen, Wan-Yu;Kuo, Sung-Hsin;Shen, Chia-Wei;Huang, Bing-Shen;Lan, Keng-Hsueh;Liang, Hsiang-Kuang;Wang, Chun-Wei, 陳婉瑜;郭頌鑫;藍耿學;梁祥光;王駿瑋   +1 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Comparison of simple and complex liver intensity modulated radiotherapy

Radiation Oncology, 2010
Background Intensity-modulated radiotherapy (IMRT) may allow improvement in plan quality for treatment of liver cancer, however increasing radiation modulation complexity can lead to increased uncertainties and requirements for quality assurance.
Eccles Cynthia L, Purdie Thomas G, Lee Mark T, Sharpe Michael B, Dawson Laura A   +4 more
doaj   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Quantification of geometric uncertainties in image guided radiotherapy [PDF]

, 2010
The aim of this thesis is to determine if the geometric uncertainties that are introduced into the image guided radiotherapy (IGRT) process by Cone Beam CT (CBCT) based IGRT equipment are sufficiently small that they do not pose a significant risk of ...
Sykes, Jonathan
core  

Toxicity and outcome of intensity-modulated radiotherapy versus 3-dimensional conformal radiotherapy for oropharyngeal cancer: A matched-pair analysis

, 2013
Because of the scarcity of randomized trials comparing toxicity and outcomes of intensity-modulated radiotherapy (IMRT) for oropharyngeal cancer (OPC) with 3D-conformal radiotherapy (3DCRT), we performed a matched-pair analysis from prospectively ...
Tans, Lisa, Tans, L. (Lisa), Teguh, D.N. (David), Rooij, P.H. (Peter) van, Teguh, DN, Al-Mamgani, Abrahim, Levendag, P.C. (Peter), Levendag, Peter, Al-Mamgani, A. (Abrahim), Rooij, Peter   +9 more
core   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

A dose homogeneity and conformity evaluation between ViewRay and pinnacle-based linear accelerator IMRT treatment plans

Journal of Medical Physics, 2014
ViewRay, a novel technology providing soft-tissue imaging during radiotherapy is investigated for treatment planning capabilities assessing treatment plan dose homogeneity and conformity compared with linear accelerator plans.
Daniel L Saenz, Bhudatt R Paliwal, John E Bayouth   +2 more
doaj   +1 more source