Results 151 to 160 of about 1,390,389 (383)

Early circulating EBV-DNA clearance predicts enhanced short-term treatment response and survival benefit in locally advanced nasopharyngeal carcinoma

BMC Cancer
Background and purpose This study investigates the correlation between the clearance of circulating Epstein-Barr virus DNA (cEBV-DNA) and treatment outcomes in locally advanced nasopharyngeal carcinoma (laNPC) patiePnts.
Xiameng Lu, Liru Zhu, Bibo Tan, Zhuowei Liang, Kaihua Chen, Suning Huang, Ling Li, Xiaodong Zhu   +7 more
doaj   +1 more source

Comparison between free breathing and deep inspiration breath hold in left-sided breast cancer treatment

Reports of Practical Oncology and Radiotherapy
BACKGROUND: This study aimed to compare the treatment plan between free breathing (FB) and deep inspiration breath-hold (DIBH) in patients with left-sided breast cancer. We aimed to investigate the dose to the heart and left lung.
Hideharu Miura, Yoshiko Doi, Soichiro Ishihara, Masahiko Kenjo, Minoru Nakao, Shuichi Ozawa, Masayuki Kagemoto   +6 more
doaj   +1 more source

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

Molecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang   +12 more
wiley   +1 more source

Further Experience with Radiotherapy in Cancer of the Corpus of the Uterus [PDF]

, 1946
J. Heyman, Sven Benner
openalex   +1 more source

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

DUAL RADIOTHERAPY IN MALIGNANT DISEASE [PDF]

, 1921
S. G. Scott
openalex   +1 more source

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma.

New England Journal of Medicine, 2005
R. Stupp, Warren P. Mason, M. J. van den Bent, M. Weller, B. Fisher, M. Taphoorn, K. Bélanger, A. Brandes, C. Marosi, U. Bogdahn, J. Curschmann, Robert C. Janzer, Samuel K. Ludwin, T. Gorlia, A. Allgeier, D. Lacombe, J. Cairncross, E. Eisenhauer, René O. Mirimanoff   +18 more
semanticscholar   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source