Results 211 to 220 of about 1,390,389 (383)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Radiotherapy for Carcinoma of the Lung [PDF]

open access: bronze, 1965
Ulla Beling, Jerzy Einhorn
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Histologic effects of endolymphatic radiotherapy [PDF]

open access: bronze, 1969
Reginald S. A. Lord, J. B. Kinmonth
openalex   +1 more source

Immunomodulation by radiotherapy in tumour control and normal tissue toxicity

open access: yesNature reviews. Immunology, 2021
U. Cytlak   +5 more
semanticscholar   +1 more source

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