Advanced Science, EarlyView.Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang +11 more
wiley +1 more source
A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity
Advanced Science, EarlyView.This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu +16 more
wiley +1 more source
Comprehensive treatment for intracranial invasive sinonasal intestinal-type adenocarcinoma with a focus on radiotherapy dosage and immunological combination therapy: A case report. [PDF]
Oncol LettYang L +7 more
europepmc +1 more source
Macrophage Extracellular Traps in Immunity and Cancer
Advanced Science, EarlyView.As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li +5 more
wiley +1 more source
Radiotherapy dosage: A neural network approach for uninvolved liver dose in stereotactic body radiation therapy for liver cancer. [PDF]
World J Gastrointest OncolKrishnan A.
europepmc +1 more source
Radiosurgery Treatment Planning via Nonlinear Programming
, 2001 The Gamma Knife is a highly specialized treatment unit that pro- vides an advanced stereotactic approach to the treatment of tumors, vascular malformations, and pain disorders within the head.
Lim, Jinho +2 more
core
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
The Toxicity of Radiotherapy for Head and Neck Tumours
, 2013 The fundamental theoretical findings Head and neck tumours make up approximately 2-3% of all malignancies in our country. There is 4 times higher occurance at men population than women one.
NESEJTOVÁ, Šárka
core
Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity
Advanced Science, EarlyView.Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu +8 more
wiley +1 more source
Balancing Tumor Control and Protecting Healthy Tissue in Radiotherapy Dosage Optimization
Radiotherapy is an important part of treating cancer because it stops tumors from growing while hurting good cells around them as little as possible. The treatment goal is to give enough radiation to effectively target and kill cancer cells while saving ...
S, Girish +6 more
core +1 more source