Results 121 to 130 of about 531,735 (303)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Symptoms 10-17 years after breast cancer radiotherapy data from the randomised SWEBCG91-RT trial

, 2010
Background: Postoperative radiotherapy decreases the risk for local and improves overall survival in women with breast cancer. We have limited information on radiotherapy-induced symptoms 10-17 years after therapy.
Sundberg, Agnetha,, Holmberg, Erik, Anderson, Harald, Karl-Axel Johansson, Malmström, Per,, Sundberg, Agnetha, David Alsadius, Alsadius, D, Alsadius, David, Johansson, Karl-Axel, Gustafsson, M, Per Malmström, Karlsson, Per, Per Karlsson, Sundberg, A, Holmberg, Erik,, Malmström, P, Wilderang, Ulrica, Dan Lundstedt, Ulrica Wilderäng, Anderson, H, Gunnar Steineck, Gustafsson, Magnus,, Erik Holmberg, Harald Anderson, Holmberg, E, Johansson, K-A, Lundstedt, D, Johansson, Karl-Axel,, Lundstedt, Dan, Lundstedt, Dan,, Karlsson, Per,, Steineck, Gunnar,, Wilderäng, U, Magnus Gustafsson, Agnetha Sundberg, Wilderäng, Ulrica,, Gustafsson, Magnus, Malmström, Per, Steineck, Gunnar, Alsadius, David,, Lund University., Steineck, G,   +42 more
core   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

TROTS - The Radiotherapy Optimisation Test Set

, 2017
The Radiotherapy Optimisation Test Set (TROTS) is an extensive set of problems originating from radiotherapy (radiation therapy) treatment planning. This dataset is created for 2 purposes: (1) to supply a large-scale dense dataset to measure performance ...
Heijmen, Ben, Breedveld, Sebastiaan, Radiotherapy   +2 more
core   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Explainable Deep Learning Model for Predicting Overall Survival in Patients Receiving Palliative Radiotherapy for Bone Metastases

Current Oncology
Purpose: Although machine learning-based prediction of overall survival (OS) in palliative radiotherapy for bone metastases has been investigated, explainable deep learning (DL) models remain underexplored.
Yui Watanabe, Takuya Tomoda, Akiko Iwata, Hirokazu Matsuno, Hiroto Hayakawa, Takeshi Nagata   +5 more
doaj   +1 more source

The Pain Relief and Recalsification Results of Radiotherapy in Plasma Cell Tumors

, 2018
37th Meeting of the European-Society-for-Radiotherapy-and-Oncology (ESTRO) -- APR 20-24, 2018 -- Barcelona, SPAINEuropean Soc Radiotherapy ...
F. Sert, Anacak, Y., Saydam, G., Sert, F., S. Kamer, Argin, M., G. Saydam, Kamer, S., M. Argın, Y. Anacak   +9 more
core   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Late toxicity after upper abdominal radiotherapy in pediatric Wilms tumor and neuroblastoma survivors. A systematic review on behalf of SIOPEN and SIOP-RTSG [PDF]

Abdominal radiotherapy; Childhood cancer; Wilms tumorRadioteràpia abdominal; Càncer infantil; Tumor de WilmsRadioterapia abdominal; Cáncer infantil; Tumor de WilmsBackground Radiotherapy plays a crucial role in the multimodal treatment of Wilms tumor ...
Timmermann , Beate, Wens, Francis, Zonca, Federica, van Tinteren, Harm, Boterberg, Tom, Laprie, Anne, Ramos Albiac, Monica   +6 more
core   +1 more source