Results 101 to 110 of about 51,909 (303)

Probabilistic optimization of dose coverage in radiotherapy [PDF]

, 2019
Background and purpose: Probabilistic optimization is an alternative to margins for handling geometrical uncertainties in treatment planning of radiotherapy where uncertainties are explicitly incorporated in the optimization.
Grusell, Erik, Grusell, Erik,, Tilly, David, Holm, Asa,, Ahnesjö, Anders,, Erik Grusell, Ahnesjö, Anders, Åsa Holm, David Tilly, Holm, Asa, Tilly, David,, Anders Ahnesjö   +11 more
core   +1 more source

Ionometric methods of calibration of iridium (192Ir) brachztherapy high activity radiation sources [PDF]

Vojnosanitetski Pregled, 2003
Milošević Nebojša T., Stanković Jovan B., Dabić-Stanković Kata M.   +2 more
doaj   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Comparing Radiotherapy alone with Chemotherapy Radiotherapy in Treatment of Patients with Stage II and III Endometrial Cancer [PDF]

, 2010
"nAbstract "nIntroduction: Endometrial cancer is the most common pelvic malignancy in women. Approximately 7,000 women die from this disease every year.
Mahdi Tabarrai, Hamid Attarian, Ahmad Mosavizadeh, Hamid Rezvani, Naghmeh Fatemi   +4 more
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Comparative evaluation of antioxidant drug influence on a radio therapy efficiency and oxidative status in mice

Russian Open Medical Journal, 2013
The aim of the study is a comparative analysis of the effect of melatonin (Melaxen) and 3-hydroxypyridine (Mexidol) on antitumor and antimetastatic influence of chemoradiotherapy and oxidative status at mice with Lewis lung carcinoma.
Alexander V. Siprov, I.M. Vashurkina, V.A. Masyagin   +2 more
doaj  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Radiotherapy for neovascular age-related macular degeneration. [PDF]

, 2010
BACKGROUND: Radiotherapy has been proposed as a treatment to prevent new vessel growth in people with neovascular age-related macular degeneration (AMD).
Chong, V, Evans, Jennifer R, Victor Chong, Chong, Victor, Evans, JR, Vasuki Sivagnanavel, Sivagnanavel, V, Jennifer R Evans, Sivagnanavel, Vasuki   +8 more
core   +1 more source

Temporal dynamics of lymphocytes in prostate cancer patients treated with proton therapy

Frontiers in Oncology
Radiotherapy can be both immunosuppressive and immunostimulatory. Radiation-induced lymphopenia (RIL) is an ongoing challenge in cancer treatment.
Sarah Salih Al-Hamami, Samuel Kurucz, Vladimír Vondráček, Vladimír Pekar, Michal Andrlík, Kateřina Dědečková, Iva Benešová, Alexandra Haas, Barbora Ondrová, Andrea Pasztorová, Pavel Vítek, Jiří Kubeš   +11 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source