Results 101 to 110 of about 501,137 (299)

The role of radiotherapy in the treatment of malignant salivary gland tumors. [PDF]

, 2005
PURPOSE: We analyzed the role of primary and postoperative low linear energy transfer radiotherapy in 538 patients treated for salivary gland cancer in centers of the Dutch Head and Neck Oncology Cooperative Group, in search for prognostic factors and ...
Levendag, P.C., Rasch, C.R., Levendag, PC, Tjho-Heslinga, R.E., Kaanders, J.H.A.M., Burlage, F.R., Levendag, Peter, Lubsen, H., Lubsen, H, Terhaard, C.H.J., Terhaard, CHJ, Tjho-Heslinga, RE, Van Den Ende, PLA, Rasch, CRN, Kaanders, HHAM, Ende, P.L. van den, Burlage, F   +16 more
core   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Comparative evaluation of antioxidant drug influence on a radio therapy efficiency and oxidative status in mice

Russian Open Medical Journal, 2013
The aim of the study is a comparative analysis of the effect of melatonin (Melaxen) and 3-hydroxypyridine (Mexidol) on antitumor and antimetastatic influence of chemoradiotherapy and oxidative status at mice with Lewis lung carcinoma.
Alexander V. Siprov, I.M. Vashurkina, V.A. Masyagin   +2 more
doaj  

Temporal dynamics of lymphocytes in prostate cancer patients treated with proton therapy

Frontiers in Oncology
Radiotherapy can be both immunosuppressive and immunostimulatory. Radiation-induced lymphopenia (RIL) is an ongoing challenge in cancer treatment.
Sarah Salih Al-Hamami, Samuel Kurucz, Vladimír Vondráček, Vladimír Pekar, Michal Andrlík, Kateřina Dědečková, Iva Benešová, Alexandra Haas, Barbora Ondrová, Andrea Pasztorová, Pavel Vítek, Jiří Kubeš   +11 more
doaj   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Hypoxia-specific MRI contrast agents

, 2018
Introduction: Hypoxia or decreased availability of oxygen in tumours is of significant interest in oncology as it is known to increase radiotherapy and chemotherapy resistance, and promote tumour progression [1, 2]. For better prognosis of solid tumours,
Wijesekera, Nadeeja (S32280), Gupta, Abhishek (R18354), Zaman, Mohammed S., Price, William S. (R10381)   +3 more
core  

A new concurrent chemotherapy with vinorelbine and mitomycin C in combination with radiotherapy in patients with locally advanced squamous cell carcinoma of the head and neck [PDF]

, 2005
Objective: The purpose of this pilot study was to evaluate the feasibility and toxicity of concurrent chemotherapy with vinorelbine and mitomycin C in combination with accelerated radiotherapy (RT) in patients with locally advanced cancer of the head and
Wilkowski, R., Schalhorn, A., Dellian, M., Dühmke, Eckhart, Pachmann, S., Schymura, B.   +5 more
core   +1 more source