Results 81 to 90 of about 51,676 (303)

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Treatment Continuity and Bone Marrow Suppression in Whole-Brain and Whole-Spinal Cord Radiotherapy for Medulloblastoma Patients

Clinical Medicine Insights: Oncology
Background: This study investigated the factors influencing treatment continuity and bone marrow suppression in whole-brain and whole-spinal cord radiotherapy for medulloblastoma, providing a clinical reference for mitigating the impact of hematological ...
Zongtai Li, Zhiyue Lin, Hui Liu, Runnan Xiao, Chuyan Lin, Wenlong Zhu, Jiaxiu Luo, Senku Xu, Feng Chi, Huilang He   +9 more
doaj   +1 more source

Type and dose of radiotherapy used for initial treatment of non-metastatic prostate cancer [PDF]

, 2014
BACKGROUND: We sought to describe patterns of initial radiotherapy among non-metastatic prostate cancer (PC) patients by recurrence risk groups. METHODS: Medical records were abstracted for a sample of 9017 PC cases diagnosed in 2004 as a part of the ...
Hamilton, Ann S., Michael Goodman, Ho, Alex, Trevor Thompson, Thompson, Trevor, Mary Lo, Alex Ho, Xiao-Cheng Wu, Dian Wang, Jean Owen, Owen, Jean, Goodman, Michael, Wang, Dian, Dian Wang, Ann S Hamilton, Fleming, Steven, Lo, Mary, Wu, Xiao-Cheng, Steven Fleming   +18 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Effect of radiotherapy on the radiopacity and flexural strength of a composite resin. [PDF]

, 2008
The aim of this study was to evaluate the effect of radiotherapy on the radiopacity and flexural strength of composite resin. Forty Z250 composite resin specimens were polymerized using a halogen light-curing unit and divided into 5 groups, in accordance
Coclete, Gilberto Aparecido [UNESP], Salzedas, Leda Maria Pescinini [UNESP], Padilha, Ana C S, Santos, Paulo Henrique dos [UNESP], Catelan, Anderson   +4 more
core   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

On-line optimization of intraoperative electron beam radiotherapy of the breast.

, 2012
PURPOSE: To optimize the dose delivery to the breast lumpectomy target treated with intraoperative electron beam radiotherapy (IOERT). MATERIALS AND METHODS: Two tools have been developed in our MU calculation software NEMO X to improve the dose ...
On line optimization of intraoperative electron beam radiotherapy of the b.r.e.a.s.t. Agostinelli S, Cavagnetto F, Zeverino M, Gusinu M, Garelli S, Guenzi M, CORVO', RENZO GIACINTO, Taccini G.   +7 more
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Predicting Factors of Radiosensitivity in Individual Radiotherapy

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2015
BACKGROUND AND OBJECTIVE: Radiation dose in oncology protocols is different for each patient according to the type and grade of the tumor, as well as adjuvant therapies.
Sh ghasemi, A Shabestani Monfared, S Borzoueisileh, E Zabihi, M Amiri, S Abedian   +5 more
doaj  

Conventional Versus Different Hypofractionated Radiotherapy Dosage Schedules in Postmastectomy Advanced Breast Cancer. [PDF]

J Med Phys, 2022
Jain N, Sharma R, Sachdeva K, Kaur A, Sudan M.   +4 more
europepmc   +1 more source