Results 81 to 90 of about 51,909 (303)

The Role of Chemotherapy in Pediatric Myoepithelial Carcinoma: A Systematic Review of the Literature

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Myoepithelial carcinoma (MEC) in pediatric patients is a rare and aggressive malignancy characterized by heterogeneous morphology and variable molecular features. The optimal role of chemotherapy remains unclear. We conducted a systematic review according to PRISMA 2020 guidelines to evaluate chemotherapy in pediatric and young‐adult patients ...
Marco Salvi, Maria Carmen Affinita, Giulia Fichera, Luisa Santoro, Angela Scagnellato, Calogero Virgone, Elena Poli, Gianni Bisogno   +7 more
wiley   +1 more source

Assessment of Dosimetric Accuracy and Plan Quality in Prostate SBRT Using RapidArc with Analysis of Varian MLC Parameters [PDF]

Iranian Journal of Medical Physics
Introduction: Prostate cancer is a highly prevalent malignancy worldwide. Advances in radiotherapy, particularly SBRT, have enabled ultra-hypofractionated treatments that improve tumor control while reducing treatment time.
Ajithkumar M, Subhankar Show, Aaditya Prakash   +2 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Neurocognitive and psychosocial late effects of cranial radiotherapy in adult survivors of childhood and adolescent cancers [PDF]

, 2018
Overview This thesis examines the late effects of cranial radiotherapy in adult survivors of childhood cancers. Part 1 is a systematic literature review which aims to extend previous research by summarising the neurocognitive outcomes associated with the
Payne, Lara
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Phase I Study of Vandetanib During and After Radiotherapy in Children With Diffuse Intrinsic Pontine Glioma [PDF]

, 2010
Purpose To evaluate the safety, maximum-tolerated dose, pharmacokinetics, and pharmacodynamics of vandetanib, an oral vascular endothelial growth factor receptor 2 (VEGFR2) and epidermal growth factor receptor inhibitor, administered once daily during ...
Kocak, Mehmet, Baker, Justin N., Chin, Thomas K., Christopher Rowland, Onar-Thomas, Arzu, Michael Tagen, Rowland, Christopher, Panandiker, Atmaram Pai, Arzu Onar-Thomas, Justin N. Baker, Leung, Wing, Atmaram Pai Panandiker, Thomas K. Chin, Clinton F. Stewart, Wing Leung, Davidoff, Andrew M., Thomas E. Merchant, Richard J. Gilbertson, Gajjar, Amar, Sue C. Kaste, Amar Gajjar, Mehmet Kocak, Broniscer, Alberto, Gilbertson, Richard J., Tagen, Michael, Stewart, Clinton F., Merchant, Thomas E., Kaste, Sue C., Andrew M. Davidoff, Alberto Broniscer   +29 more
core   +1 more source

Treatment Continuity and Bone Marrow Suppression in Whole-Brain and Whole-Spinal Cord Radiotherapy for Medulloblastoma Patients

Clinical Medicine Insights: Oncology
Background: This study investigated the factors influencing treatment continuity and bone marrow suppression in whole-brain and whole-spinal cord radiotherapy for medulloblastoma, providing a clinical reference for mitigating the impact of hematological ...
Zongtai Li, Zhiyue Lin, Hui Liu, Runnan Xiao, Chuyan Lin, Wenlong Zhu, Jiaxiu Luo, Senku Xu, Feng Chi, Huilang He   +9 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Type and dose of radiotherapy used for initial treatment of non-metastatic prostate cancer [PDF]

, 2014
BACKGROUND: We sought to describe patterns of initial radiotherapy among non-metastatic prostate cancer (PC) patients by recurrence risk groups. METHODS: Medical records were abstracted for a sample of 9017 PC cases diagnosed in 2004 as a part of the ...
Hamilton, Ann S., Michael Goodman, Ho, Alex, Trevor Thompson, Thompson, Trevor, Mary Lo, Alex Ho, Xiao-Cheng Wu, Dian Wang, Jean Owen, Owen, Jean, Goodman, Michael, Wang, Dian, Dian Wang, Ann S Hamilton, Fleming, Steven, Lo, Mary, Wu, Xiao-Cheng, Steven Fleming   +18 more
core   +1 more source