Results 71 to 80 of about 501,137 (299)

Comparison of predicted and actual dermatitis generated from computed tomography images and dose distribution maps

Technical Innovations & Patient Support in Radiation Oncology
Anticipating the onset, location and severity of radiation dermatitis before radiotherapy can aid in dermatological care. This study developed a method for creation of a prediction diagram for dermatitis and conducted a comparative verification between ...
Yasuhide Miyabe, Saori Oshiro, Hiroto Seki, Yusuke Muroi, Eriko Kawashima, Megumi Hosoda, Kento Ohashi, Hiromu Yamanaka, Mingliang Shao, Hiromi Sugawara, Jyunetsu Mizoe, Ritsuko Komaki   +11 more
doaj   +1 more source

Recent advances in radiotherapy and its associated side effects in cancer—a review

Journal of Basic and Applied Zoology, 2019
Background Radiotherapy (RT) is the chief nonsurgical method to control malignant tumors. RT has advanced in both methodological and biological aspects over the past few decades.
Gomathi Mohan, Ayisha Hamna T P, Jijo A J, Saradha Devi K M, Arul Narayanasamy, Balachandar Vellingiri   +5 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Comparative evaluation of influence of drugs with antioxidant effect on therapeutic efficiency of radiotherapy and oxidative status in mice [PDF]

Саратовский научно-медицинский журнал, 2012
<p><em style="font-size: 12px;">The purpose of the study </em><span style="font-size: 12px;">is to carry out a comparative analysis of the effect of melatonin (melaxen) and of 3-hy-droxypyridine (mexidol) on ...
Masyagin V.A., Vashurkina I.M., Siprov A.M.   +2 more
doaj  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Profile of European radiotherapy departments contributing to the EORTC Radiation Oncology Group (ROG) in the 21st century

, 2008
Since 1982, the Radiation Oncology Group of the EORTC (EORTC ROG) has pursued an extensive Quality Assurance (QA) program involving all centres actively participating in its clinical research.
Collette, L., Budiharto, Tom, Hurkmans, Coen, Aird, Edwin, Musat, Elena, Duclos, F., Davis, Bernard, Poortmans, P., Aird, E., Monti, A., Monti, Angelo, Musat, E., Collette, Laurence, Bar-Deroma, R., Davis, B., Bernstein, Zvi, van Tienhoven, Geertjan, Poortmans, Philip, Tienhoven, G., Hurkmans, C., Bar-Deroma, Raquel, Duclos, Frédéric, Bernstein, Z., Budiharto, T.   +23 more
core   +1 more source

Lost in the Vaso‐Occlusion: A Patient's Abdominal Pain Returns With a Vengeance

Pediatric Blood &Cancer, EarlyView.
Dunia Hatabah, Martha E. Stewart, Nathan Maassel, James P. Stevens, Claudia R. Morris, Chris A. Rees   +5 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Coping of cancer patients during and after radiotherapy - a follow-up of 2 years [PDF]

, 2003
Aim: We wanted to understand coping strategies specific to different phases up to two years after radiotherapy, to identify patients who are at higher risk of mood disturbances and to characterise the association between coping strategies and ...
Fahmüller, H., Sehlen, Susanne, Herschbach, P., Aydemir, U., Lenk, M., Dühmke, Eckhart, Hollenhorst, H., Schymura, B., Song, R., Sehlen, S;Song, R;Fahmüller, H;Herschbach, P;Lenk, M;Hollenhorst, H;Schymura, B;Aydemir, U;Duhmke, E, Sehlen, S.;Song, R.;Fahmüller, H.;Herschbach, P.;Lenk, M.;Hollenhorst, H.;Schymura, B.;Aydemir, U.;Dühmke, E.   +10 more
core   +1 more source