Results 71 to 80 of about 51,676 (303)

Abnormal Nuclear Variations in Response to Radiotherapy- As a Tool in Treatment Planning and Assessment of Prognosis [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: The treatment approaches for oral squamous cell carcinoma (OSCC) include single management with surgery, radiotherapy, along with chemotherapy or various combinations of these modalities.
Kumar Satish Ravi, Manisha Naithani, Sohinder Kaur, K.S. Reddy, Rachna Pasi   +4 more
doaj   +1 more source

Preoperative radiotherapy improves outcome in recurrent rectal cancer

, 2005
PURPOSE: When local recurrent rectal cancer is diagnosed without signs of metastases, a potentially curative resection can be performed. This study was designed to compare the results of preoperative radiotherapy followed by Surgery with surgery only ...
de Wilt, JHW, Marinelli, AWKS, Verhoef, C, Ferenschild, FTJ, Nuyttens, JJME, Vermaas, M, Wiggers, T, van der Sijp, JRMM, Eggermont, AMM, Graveland, WJ   +9 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Assessment of Dosimetric Accuracy and Plan Quality in Prostate SBRT Using RapidArc with Analysis of Varian MLC Parameters [PDF]

Iranian Journal of Medical Physics
Introduction: Prostate cancer is a highly prevalent malignancy worldwide. Advances in radiotherapy, particularly SBRT, have enabled ultra-hypofractionated treatments that improve tumor control while reducing treatment time.
Ajithkumar M, Subhankar Show, Aaditya Prakash   +2 more
doaj   +1 more source

Otitis media with effusion after radiotherapy of the head and neck:a systematic review

, 2018
BACKGROUND: Otitis media (OM) and associated hearing problems may be side effects to radiotherapy of the head and neck region and affect patient quality of life.
Wessel, I, P. Homøe, Homøe, P, Gothelf, A B, Christensen, J G, I. Wessel, A. B. Gothelf, J. G. Christensen   +7 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Neurocognitive and psychosocial late effects of cranial radiotherapy in adult survivors of childhood and adolescent cancers [PDF]

, 2018
Overview This thesis examines the late effects of cranial radiotherapy in adult survivors of childhood cancers. Part 1 is a systematic literature review which aims to extend previous research by summarising the neurocognitive outcomes associated with the
Payne, Lara
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Modern radiotherapy techniques

, 2019
Cilj ovog preglednog rada je prikazati nove sofisticirane metode radioterapije koje su se razvile zahvaljujući napretku tehnologije unazad par desetljeća. Osvrnut ćemo se na njihove prednosti i nedostatke, važnost slikovne obrade, preciznog konturiranja,
Beketić-Orešković, Lidija, Ravlić, Mirna, Solak-Mekić, Meliha, Cmrečak, Franjo, Andrašek, Iva, Iva Andrašek, Mirna Ravlić, Meliha Solak-Mekić, Lidija Beketić-Orešković, Franjo Cmrečak   +9 more
core   +1 more source