Results 61 to 70 of about 501,137 (299)
Dosage-response profiles of all predictor genes.
, 2023 We computed the dosage-response profiles for all predictor genes in 200 genetic backgrounds by individually tuning the corresponding dosage from g = 0 to g = 1 and computing the growth rate with FBA. Observe that i) all top predictors (with β > 0.01) are
Alvar A. Lavin (17373676) +2 more
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Journal of Health Sciences, 2011 Introduction: The aim of this paper is to study the distribution of the therapy dosage applied by a modified conventional “field in field” technique and compare it to the distribution of the dosage applied by the standard conventional technique. Methods:
Goran Marošević +4 more
doaj +1 more source
Palliative chemotherapy followed by consolidation radiotherapy in patients with advanced and metastatic non-small cell lung cancer not suitable for radical treatment [PDF]
Archive of Oncology, 2012 Background: This is a retrospective study to assess the effectiveness of consolidation radiotherapy (CRT) following palliative chemotherapy in patients with metastatic or locally advanced non-small cell lung cancer (NSCLC) who are not suitable for ...
Eldeeb Hany, Camileri Philip, Mak Choi
doaj +1 more source
Pediatric Mediastinal Gray Zone Lymphoma With Germline TET2 Heterozygous Variant
Pediatric Blood &Cancer, EarlyView.
Matthew R. Schuelke +9 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Use of radiobiological modeling in treatment plan evaluation and optimization of prostate cancer radiotherapy [PDF]
, 2011 There are many tools available that are used to evaluate a radiotherapy treatment plan, such as isodose distribution charts, dose volume histograms (DVH), maximum, minimum and mean doses of the dose distributions as well as DVH point dose constraints ...
Baltas, Dimos +8 more
core +1 more source
Principle of Cancer Radiotherapy
, 2021 Radiotherapy is one of the most common types of nonsurgical anticancer treatment modality, employed in more than 50% of cases. Almost half of cancer patients are cured of their cancer by radiotherapy as part of their anticancer treatment.
Lee, VHF, Lee, WMA
core +1 more source
Journal of Contemporary Brachytherapy, 2010 Purpose: Lip cancer can be treated by surgery, external radiotherapy, and/or brachytherapy (BT). In recent years,BT has become increasingly favored for this type of cancer.
Ferran Guedea +4 more
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