Results 51 to 60 of about 501,137 (299)

Evaluation of the Lung Volume Changes in Patients with Breast Cancer Based on the Received Dose in the Upper and Lower Lobes of the Lung

مجله دانشکده پزشکی اصفهان, 2019
Background: The development of pulmonary complications after breast radiotherapy is still controversial. These complications might result in temporary or permanent damage to the lung.
Seyedeh Mahsa Abdemanafi, Mohammad Bagher Tavakoli, Ali Akhavan, Iraj Abedi   +3 more
doaj   +1 more source

External beam radiotherapy inhibits stent related granulation hyperplasia in rabbit trachea

Scientific Reports, 2023
Endobronchial stent exacerbates the formation of granulation tissue. Radiotherapy maybe a durable treatment option for granulation hyperplasia. In this study, we explore the results of external beam radiotherapy (EBRT) for granulation hyperplasia after ...
Zihe Zhou, Bin Han, Kewei Ren, Yahua Li, Kunpeng Wu, Janan Wang, Yifan Li, Zongming Li, Xinwei Han   +8 more
doaj   +1 more source

Effect of the normal liver mean dose on intrahepatic recurrence in patients with hepatocellular carcinoma after receiving liver stereotactic body radiation therapy

Translational Oncology, 2022
Background and purpose: This study aims to evaluate whether dosimetric parameters affect the intrahepatic out-field recurrence or distant metastasis-free survival following the stereotactic body radiation therapy (SBRT) in patients with hepatocellular ...
Qi-Qiao Wu, Yi-Xing Chen, Shi-Suo Du, Yong Hu, Ping Yang, Jing Sun, Xin-Yue Wang, Wei-Xun Wu, Shu-Min Zhang, Zhao-Chong Zeng   +9 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Combining spatially fractionated radiation therapy (SFRT) and immunotherapy opens new rays of hope for enhancing therapeutic ratio

Clinical and Translational Radiation Oncology
Spatially Fractionated Radiation Therapy (SFRT) is a form of radiotherapy that delivers a single large dose of radiation within the target volume in a heterogeneous pattern with regions of peak dosage and regions of under dosage.
Qiuxia Lu, Weisi Yan, Alan Zhu, Slavisa Tubin, Waleed F. Mourad, Jun Yang   +5 more
doaj   +1 more source

Quimera: a simulation platform based on the code Geant4 for dose evaluation in radiotherapy

Brazilian Journal of Radiation Sciences, 2018
This work describes the development and validation of a simulation platform, called Quimera, based on the Monte Carlo (MC) code Geant4 for dose evaluation in radiotherapy.
Alex Cristóvão Holanda de Oliveira, Jose Wilson Vieira, Fernando Roberto de Andrade Lima   +2 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

A study of the clinical, treatment planning and dosimetric feasibility of dose painting in external beam radiotherapy of prostate cancer

Physics and Imaging in Radiation Oncology, 2020
Background and purpose: Radiotherapy dose painting is a promising technique which enables dose escalation to areas of higher tumour cell density within the prostate which are associated with radioresistance, known as dominant intraprostatic lesions (DILs)
Steve W. Blake, Alison Stapleton, Andrew Brown, Sian Curtis, Janice Ash-Miles, Emma Dennis, Susan Masson, Dawn Bowers, Serena Hilman   +8 more
doaj   +1 more source

Mesenchymal Stem Cells for Mitigating Radiotherapy Side Effects

Cells, 2021
Radiation therapy for cancers also damages healthy cells and causes side effects. Depending on the dosage and exposure region, radiotherapy may induce severe and irreversible injuries to various tissues or organs, especially the skin, intestine, brain ...
Kai-Xuan Wang, Wen-Wen Cui, Xu Yang, Ai-Bin Tao, Ting Lan, Tao-Sheng Li, Lan Luo   +6 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source