Results 91 to 100 of about 51,676 (303)

Development of Physics Applied to Medicine in the UK, 1945–90

, 2006
Annotated and edited transcript of a Witness Seminar held on 5 July 2005. Introduction by Dr Jeff Hughes.First published by the Wellcome Trust Centre for the History of Medicine at UCL, 2006.©The Trustee of the Wellcome Trust, London, 2006.All volumes ...
Christie, DA, Tansey, EM
core  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Evaluation of Calculation Errors of Treatment Planning System in Dose Distribution of Electron Beams inside the Lung in Three-Dimensional Conformal Radiation Therapy (3D-CRT)

مجله دانشکده پزشکی اصفهان, 2017
Background: Calculation of dose distribution of electron beams within in homogeneities may be complex for some of treatment planning systems (TPS). The aim of this study was to investigate the calculation errors of targeted image-guided radiation therapy
Mohammad Bagher Tavakoli, Hossein Taheri, Ali Akhavan   +2 more
doaj  

Protection during radiotherapy: selenium

The multifaceted applications of nuclear technology, especially in cancer treatment through radiotherapy, bring considerable benefits to our daily lives but also necessitate the imperative for effective strategies to effectively mitigate radiation ...
D. Li, J. Yan
core   +1 more source

Analysis of GTV reduction during radiotherapy for oropharyngeal cancer: Implications for adaptive radiotherapy

, 2017
Adaptive field size reduction based on gross tumor volume (GTV) shrinkage imposes risk on coverage. Fiducial markers were used as surrogate for behavior of tissue surrounding the GTV edge to assess this risk by evaluating if GTVs during treatment are ...
Lange, Charlotte A.H., Lange, Charlotte A. H., Heemsbergen, Wilma D., Heemsbergen, W.D., Sonke, Jan Jakob, Rasch, Coen R. N., Rasch, C.R.N., van den Brekel, Michiel W. M., van den Brekel, Michiel W.M., Lange, C.A.H., van Kranen, Simon R., Verheij, Marcel, Hamming-Vrieze, Olga, Brekel, M.W.M. van den, Rasch, Coen R.N., Verheij, M., Sonke, J.J., Hamming-Vrieze, O., Kranen, S.R. van   +18 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Ionometric methods of calibration of iridium (192Ir) brachztherapy high activity radiation sources [PDF]

Vojnosanitetski Pregled, 2003
Milošević Nebojša T., Stanković Jovan B., Dabić-Stanković Kata M.   +2 more
doaj   +1 more source

The abscopal effect of local radiotherapy: using immunotherapy to make a rare event clinically relevant.

, 2015
BACKGROUND: Recently, immunologic responses to localized irradiation are proposed as mediator of systemic effects after localized radiotherapy (called the abscopal effect).
Tim Illidge, Reynders, Kobe, Siva, Shankar, Joe Y. Chang, Dirk De Ruysscher, Kobe Reynders, De Ruysscher, Dirk, Shankar Siva, Illidge, Tim; id_orcid, Chang, Joe Y   +9 more
core   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Temporal dynamics of lymphocytes in prostate cancer patients treated with proton therapy

Frontiers in Oncology
Radiotherapy can be both immunosuppressive and immunostimulatory. Radiation-induced lymphopenia (RIL) is an ongoing challenge in cancer treatment.
Sarah Salih Al-Hamami, Samuel Kurucz, Vladimír Vondráček, Vladimír Pekar, Michal Andrlík, Kateřina Dědečková, Iva Benešová, Alexandra Haas, Barbora Ondrová, Andrea Pasztorová, Pavel Vítek, Jiří Kubeš   +11 more
doaj   +1 more source