Results 61 to 70 of about 14,201 (265)

A Fuzzy Non-linear Similarity Measure for Case-Based Reasoning Systems for Radiotherapy Treatment Planning

, 2010
International audienceThis paper presents a decision support system for treatment planning in brain cancer radiotherapy. The aim of a radiotherapy treatment plan is to apply radiation in a way that destroys tumour cells but minimizes the damage to ...
Angela McKenna, Louise Newton, Jagannathan, Rupa, Mckenna, Angela, Newton, Louise, Rupa Jagannathan, Sanja Petrovic, Petrovic, Sanja   +7 more
core   +1 more source

Liquid Metal Nanotransformers for Drug‐Resistant Pan‐Cancer Therapy in Patient‐Derived Organoids

Advanced Science, EarlyView.
Pan‐cancer therapies are severely limited in drug‐resistance patients due to genetic mutations and other factors, resulting in poor therapeutic outcomes and constrained clinical benefit. Liquid metal nanotransformers, a new class of shape‐transformable nanomaterials capable of dramatic morphological changes, offer a promising physical strategy to ...
Xiaojie Yuan, Xuelin Wang, Zhongyao Chen, Shuo Wang, Weining Gao, Ziyi Chen, Runyang Li, Cheng Hao, Lei Zhang, Qiongqiong Zhang, Ke Zhang, Mei Yu, Qian Liu, Jingxuan Wang, Huiping Li, Simpkins Fiona, Jing Liu, Qiang Liu, Peng Liu, Yawei Hu   +19 more
wiley   +1 more source

Multicentre prospective risk analysis of a fully automated radiotherapy workflow

Physics and Imaging in Radiation Oncology
Background and Purpose: Fully automated workflows (FAWs) for radiotherapy treatment preparation are feasible, but remain underutilized in clinical settings.
Geert De Kerf, Ana Barragán-Montero, Charlotte L. Brouwer, Pietro Pisciotta, Marie-Claude Biston, Marco Fusella, Geoffroy Herbin, Esther Kneepkens, Livia Marrazzo, Joshua Mason, Camila Panduro Nielsen, Koen Snijders, Stephanie Tanadini-Lang, Aude Vaandering, Tomas M. Janssen   +14 more
doaj   +1 more source

Nanozymes for Advanced Hemoglobin‐Based Oxygen Carriers: Applications in Blood Substitution, Wound Healing, Antitumor Therapy, and Beyond

Advanced Science, EarlyView.
This review explores how hemoglobin‐based oxygen carriers (HBOCs) combined with nanozymes create multifunctional materials that deliver oxygen while maintaining redox homeostasis. Beyond artificial blood substitutes, these constructs enable wound healing with light‐triggered oxygen release, cancer therapy through enhanced oxygenation and reactive ...
Despoina Douka, Ana María Pablo‐Sainz‐Ezquerra, Eva Jakljevič, Niki Ktena, Leticia Hosta‐Rigau   +4 more
wiley   +1 more source

Target coverage in image-guided stereotactic body radiotherapy of liver tumors

, 2007
PURPOSE: To determine the effect of image-guided procedures (with computed tomography [CT] and electronic portal images before each treatment fraction) on target coverage in stereotactic body radiotherapy for liver patients using a stereotactic body ...
Vásquez Osorio, Eliana M; id_orcid, Heijmen, Ben J M, Heijmen, Ben, Brandwijk, Rene, Méndez Romero, Alejandra, Wunderink, Wouter, Levendag, Peter, Brandwijk, René P, Levendag, Peter C, Vasquez Osorio, Eliana, Boer, Hans, de Boer, Hans C J   +11 more
core   +1 more source

Single‐Cell Reveal GALNT7‐Dependent Ferroptosis Suppression as a Mechanism of Immunotherapy Resistance in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
Integrated clinical and mechanistic analyses identify GALNT7 as a ferroptosis‐suppressive regulator associated with immunotherapy resistance in non‐small cell lung cancer. GALNT7 depletion promotes lipid peroxidation, mitochondrial dysfunction, and ferroptosis, enhances CD8+ T‐cell activation and IFN‐γ production, and sensitizes tumors to PD‐1 blockade,
Jiadi Gan, Qian Zheng, Deng Liu, Ruichao Nie, Menglin Yao, Xiaolong Tang, Renjie Xu, Jinghong Xian, Wenjun Meng, Wenxin Luo, Dan Liu, Guiyi Ji   +11 more
wiley   +1 more source

Biomimetic Macrophage Cell Membrane‐Based Nanoparticles for Effective Treatment of Glioblastoma Through Boron Neutron Capture Therapy Combined With Immunotherapy

Advanced Science, EarlyView.
ABSTRACT Glioblastoma multiforme (GBM) remains largely incurable due to the blood‐brain barrier (BBB) and immunosuppressive microenvironment. While boron neutron capture therapy (BNCT) selectively eradicates tumor cells via 10B(n, α)‐7Li reactions, its clinical potential in GBM is unrealized because of the suboptimal pharmacokinetics of conventional ...
Jiawen Chen, Haoyu You, Hefa Huang, Huihui Chai, Ruize Zhu, Yun Guan, Qisheng Tang, Tianwen Li, Shan Jiang, Houshi Xu, Peng Wang, Yue Wang, Maoyuan Sun, Beining Liu, Zhen Li, Yulai Zeng, Weiqiu Ping, Yanlin Teng, Songlin Yan, Qinghui Li, Long Gu, Tao Sun, Zhifeng Shi   +22 more
wiley   +1 more source

Impact of Abdominoperineal Resection on Postoperative Male Sexual Function After Minimally Invasive Rectal Cancer Surgery: A Subgroup Analysis From the LANDMARC Study

Annals of Gastroenterological Surgery, EarlyView.
Abdominoperineal resection (APR) after minimally invasive rectal cancer surgery was associated with significantly higher rates of erectile and early ejaculatory dysfunction compared with anal‐sparing surgery. Although ejaculatory function showed partial recovery over time, erectile dysfunction persisted up to 12 months postoperatively.
Taiki Kajiwara, Shinobu Ohnuma, Michiaki Unno, Masakatsu Numata, Tomohiro Yamaguchi, Koya Hida, Tomonori Akagi, Suguru Hasegawa, Akio Shiomi, Ryo Inada, Manabu Shiozawa, Keisuke Kazama, Masanori Hotchi, Masahiko Watanabe, Takeshi Naitoh   +14 more
wiley   +1 more source

Dosimetric Evaluation of Volumetric Modulated Arc Therapy (VMAT) and Intensity Modulated Radiotherapy (IMRT) Using AAPM TG 119 Protocol

Journal of Biomedical Physics and Engineering, 2019
Background: The commissioning accuracy of Volumetric Modulated Arc Therapy (VMAT) need to be evaluated. Objective: To test and evaluate commissioning accuracy of VMAT based on the TG 119 protocols at local institution.
Nainggolan A., Pawiro S. A.
doaj  

Palliative radiotherapy of soft tissue tumoral masses based on diagnostic instead of planning computed tomography scans

Physics and Imaging in Radiation Oncology
Background and purpose: Radiotherapy (RT) treatment planning is based on a planning computed tomography scan (pCT), while the decision to treat is often already established on a diagnostic CT scan (dCT).
Satu Strengell, Suvi Larjavaara, Mikko Tenhunen, Anu Anttonen   +3 more
doaj   +1 more source