Results 11 to 20 of about 25,765 (263)

Detection of Mutations in Exon 8 of TP53 by Temperature Gradient 96-Capillary Array Electrophoresis

open access: yesBioTechniques, 2002
Various capillary electrophoresis applications have increasingly been utilized in mutation detection. Separation of two species is either based on secondary structure or differences in melting of DNA due to the mutation.
A. Torgunrud Kristensen   +4 more
doaj   +1 more source

Automated Constant Denaturant Capillary Electrophoresis Applied for Detection of KRAS Exon 1 Mutations

open access: yesBioTechniques, 2001
In this study, we have applied automated constant denaturant capillary electrophoresis (ACDCE) for the detection of KRAS exon 1 mutations. Samples from 191 sporadic colon carcinomas previously analyzed for KRAS mutations with allele-specific PCR (ASPCR),
J. Bjørheim   +4 more
doaj   +1 more source

Dose in biota due to alpha radionuclide emitters in a dan associated with a uranium mining

open access: yesBrazilian Journal of Radiation Sciences, 2020
Introdução: A  radioproteção tem como foco a proteção dos seres humanos e seus descendentes e a proteção do meio ambiente. A proteção ambiental sempre foi feita de forma indireta por meio da proteção do ser humano no meio ambiente.
Wagner De Souza Pereira   +7 more
doaj   +1 more source

Clinical outcomes and treatment patterns in REASSURE: planned interim analysis of a real-world observational study of radium-223 in metastatic castration-resistant prostate cancerResearch in context

open access: yesEClinicalMedicine, 2023
Summary: Background: Radium-223, a targeted alpha therapy, is approved to treat bone-dominant metastatic castration-resistant prostate cancer (mCRPC), based on significantly prolonged overall survival versus placebo and a favourable safety profile in ...
Celestia S. Higano   +14 more
doaj   +1 more source

Evaluation of arrayed primer extension for TP53 mutation detection in breast and ovarian carcinomas

open access: yesBioTechniques, 2005
Mutations in the tumor suppressor gene TP53 are associated with a wide range of different cancers and may have prognostic and therapeutic implications. Methods for rapid and sensitive detection of mutations in this gene are therefore required.
Pedro Kringen   +8 more
doaj   +1 more source

Radium-223 for metastatic, castration-resistant prostate cancer: A retrospective chart review study of real-world use in a tertiary hospital in Taiwan

open access: yesJournal of the Formosan Medical Association, 2022
Background: Radium-223 is an alpha-emitting, bone-targeting radiopharmaceutical that confers a survival benefit in patients with confirmed bone-metastatic, castration-resistant prostate cancer with no visceral metastases.
Wei-Chun Weng   +3 more
doaj   +1 more source

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