Results 21 to 30 of about 38,948 (266)

Radium-223 as an Additional Therapeutic Strategy in Highly Selected Patients With Metastatic Breast Cancer: A Case Report

Frontiers in Oncology, 2022
Radium-223 is commonly used in metastatic prostate cancer, targeting specifically bone metastases. The use of radium-223 remains, however, poorly evaluated in metastatic breast cancer.
Hélène Houssiau, Francois P. Duhoux, Didier François, Emmanuel Seront   +3 more
doaj   +1 more source

Sorption pre/concentration of alkaline earth elements from natural waters within the method of radiochemical analysis

Водное хозяйство России: проблемы, технологии, управление, 2022
Development of novel methods of the radiochemical analysis for natural and artificial radionuclides is one of the most urgent current tasks. Th is work deals with studying of laws of sorption pre/concentration of strontium and radium radionuclides in ...
Vladimir S. Semenishchev, Anna V. Voronina, Svetlana M. Titova, Yulia I. Nasonova, Maria A. Cherepanova   +4 more
doaj   +1 more source

The problem of skipped generation and subclinical disease in familial breast‐ovarian cancer

Acta Obstetricia et Gynecologica Scandinavica, 1997
Background. The major gene for inherited breast ovarian cancer families shows high penetrance in female carriers. Daughters of living unaffected women in these families are supposed to have a low risk of cancer.
Anne Dørum, Vera M. Abeler, Ketil Heimdal, Claes Tropé, Pål Møller   +4 more
doaj   +1 more source

Extended X-ray absorption fine structure spectroscopy measurements and ab initio molecular dynamics simulations reveal the hydration structure of the radium(II) ion

iScience, 2022
Summary: Radium is refocused from the viewpoint of an environmental pollutant and cancer therapy using alpha particles, where it mainly exists as a hydrated ion.
Akiko Yamaguchi, Kojiro Nagata, Keita Kobayashi, Kazuya Tanaka, Tohru Kobayashi, Hajime Tanida, Kojiro Shimojo, Tetsuhiro Sekiguchi, Yui Kaneta, Shohei Matsuda, Keiichi Yokoyama, Tsuyoshi Yaita, Takashi Yoshimura, Masahiko Okumura, Yoshio Takahashi   +14 more
doaj   +1 more source

Naturally occurring radium (Ra) in home drinking‐water wells in the Sandhills region of South Carolina, USA: Can high concentrations be predicted?

GeoHealth, 2017
A strong relationship exists between concentrations of several principal constituents of water chemistry and naturally occurring radium in water from home wells in the large Sandhills region of the inner coastal plain of South Carolina, United States, an
Jeffrey M. Schrag
doaj   +1 more source

[223Ra] RaCl2 nanomicelles showed potent effect against osteosarcoma: targeted alpha therapy in the nanotechnology era

Drug Delivery, 2022
The treatment of bone metastatsis as primary bone cancer itself is still a challenge. The use od radium dichloride ([223Ra] RaCl2) has emerged in the last few years as one of the best treatment choice for bone cancer, with especial focus in bone ...
Yang Yang, Luciana Magalhães Rebelo Alencar, Martha Sahylí Ortega Pijeira, Beatriz da Silva Batista, Alefe Roger Silva França, Erick Rafael Dias Rates, Ruana Cardoso Lima, Sara Gemini-Piperni, Ralph Santos-Oliveira   +8 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

An analysis of hazard indices based on the transfer factor of naturally occurring radionuclides in herbal infusions [PDF]

Anais da Academia Brasileira de Ciências
The transfer factor is an important concept for assessing hazard indices associated with radionuclide intake. In this study, radionuclide transfer factors were determined for the infusion process using gamma spectrometry.
ROBERTO C. SILVA, JOSÉ M. LOPES, LUCAS F. SILVA, ALESSANDRO M. DOMINGUES, WAGNER S. PEREIRA, ADEMIR X. SILVA   +5 more
doaj   +1 more source

Relapsing–Remitting Multiple Sclerosis Is Associated With a Dysbiotic Oral Microbiome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation, demyelination, and neurological impairment. While the gut microbiota's role in MS is extensively studied, the association between the oral microbiota and MS remains underexplored, particularly in North American cohorts.
Sukirth M. Ganesan, Meeta Yadav, Sudeep Ghimire, Peter C. Lehman, Apurva J. Patel, Sydney Woods, Heena Olalde, Jemmie Hoang, Mishelle Paullus, Catherine Cherwin, Christine Gill, Tracey Cho, Ashutosh K. Mangalam   +12 more
wiley   +1 more source