Results 21 to 30 of about 25,142 (257)

Radium-223 as an Additional Therapeutic Strategy in Highly Selected Patients With Metastatic Breast Cancer: A Case Report

Frontiers in Oncology, 2022
Radium-223 is commonly used in metastatic prostate cancer, targeting specifically bone metastases. The use of radium-223 remains, however, poorly evaluated in metastatic breast cancer.
Hélène Houssiau, Francois P. Duhoux, Didier François, Emmanuel Seront   +3 more
doaj   +1 more source

The problem of skipped generation and subclinical disease in familial breast‐ovarian cancer

Acta Obstetricia et Gynecologica Scandinavica, 1997
Background. The major gene for inherited breast ovarian cancer families shows high penetrance in female carriers. Daughters of living unaffected women in these families are supposed to have a low risk of cancer.
Anne Dørum, Vera M. Abeler, Ketil Heimdal, Claes Tropé, Pål Møller   +4 more
doaj   +1 more source

Extended X-ray absorption fine structure spectroscopy measurements and ab initio molecular dynamics simulations reveal the hydration structure of the radium(II) ion

iScience, 2022
Summary: Radium is refocused from the viewpoint of an environmental pollutant and cancer therapy using alpha particles, where it mainly exists as a hydrated ion.
Akiko Yamaguchi, Kojiro Nagata, Keita Kobayashi, Kazuya Tanaka, Tohru Kobayashi, Hajime Tanida, Kojiro Shimojo, Tetsuhiro Sekiguchi, Yui Kaneta, Shohei Matsuda, Keiichi Yokoyama, Tsuyoshi Yaita, Takashi Yoshimura, Masahiko Okumura, Yoshio Takahashi   +14 more
doaj   +1 more source

Naturally occurring radium (Ra) in home drinking‐water wells in the Sandhills region of South Carolina, USA: Can high concentrations be predicted?

GeoHealth, 2017
A strong relationship exists between concentrations of several principal constituents of water chemistry and naturally occurring radium in water from home wells in the large Sandhills region of the inner coastal plain of South Carolina, United States, an
Jeffrey M. Schrag
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

[223Ra] RaCl2 nanomicelles showed potent effect against osteosarcoma: targeted alpha therapy in the nanotechnology era

Drug Delivery, 2022
The treatment of bone metastatsis as primary bone cancer itself is still a challenge. The use od radium dichloride ([223Ra] RaCl2) has emerged in the last few years as one of the best treatment choice for bone cancer, with especial focus in bone ...
Yang Yang, Luciana Magalhães Rebelo Alencar, Martha Sahylí Ortega Pijeira, Beatriz da Silva Batista, Alefe Roger Silva França, Erick Rafael Dias Rates, Ruana Cardoso Lima, Sara Gemini-Piperni, Ralph Santos-Oliveira   +8 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

An analysis of hazard indices based on the transfer factor of naturally occurring radionuclides in herbal infusions [PDF]

Anais da Academia Brasileira de Ciências
The transfer factor is an important concept for assessing hazard indices associated with radionuclide intake. In this study, radionuclide transfer factors were determined for the infusion process using gamma spectrometry.
ROBERTO C. SILVA, JOSÉ M. LOPES, LUCAS F. SILVA, ALESSANDRO M. DOMINGUES, WAGNER S. PEREIRA, ADEMIR X. SILVA   +5 more
doaj   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Tratamento do Câncer do Lábio Inferior pelo Aplicador Duplo de Radium

Revista Brasileira de Cancerologia, 2023
A técnica de tratamento do câncer do lábio inferior pelo aplicador duplo de radium. Sua infra-estrutura material. O exercício da técnica no Instituto Nacional de Câncer. Tipo de lesão estudada. Modalidades de tratamento.
Antônio Saul Gutman
doaj   +1 more source