Results 111 to 120 of about 95,461 (311)

Geometrically Encoded Positioning of Introns, Intergenic Segments, and Exons in the Human Genome

Advanced Science, EarlyView.
This study introduces a new hypothesis: exons, introns, and intergenic segments are non‐random projections of the functional layers of 3D structure of chromatin packing domains. Evidence is presented that this “geometric code” may encode volumetric structure, reconciling epigenetic patterns, correlates with oncogenic mutations, acting as a potential ...
Luay M. Almassalha, Kyle L. MacQuarrie, Marcelo Carignano, Cody L. Dunton, Ruyi Gong, Joe Ibarra, Lucas M. Carter, Wing Shun Li, Rikkert Nap, Parambir S. Dulai, Igal Szleifer, Vadim Backman   +11 more
wiley   +1 more source

IAEA Safety Guides vs. Actual Challenges for Design and Conduct of Indoor Radon Surveys

Atmosphere
An analysis of the international radon regulatory framework identified actual challenges for the design and conduct of indoor radon surveys, though there is little discussion on this issue in the radon community.
Andrey Tsapalov, Konstantin Kovler, Sergey Kiselev, Ilia Yarmoshenko, Robert Bobkier, Petr Miklyaev   +5 more
doaj   +1 more source

Improved Approach for the Investigation of Submarine Groundwater Discharge by Means of Radon Mapping and Radon Mass Balancing

Water, 2019
The paper presents an improved approach for investigating submarine groundwater discharge (SGD) based on radon mapping and radon mass balancing in the coastal sea.
M. Schubert, E. Petermann, R. Stollberg, M. Gebel, J. Scholten, K. Knöller, C. Lorz, Franziska Glück, K. Riemann, H. Weiss   +9 more
semanticscholar   +1 more source

Volumetric Additive Manufacturing of Dormant Catalytic Chemistries to Generate Silicone Micro‐ and Millifluidic Devices and Instant Molds

Advanced Science, EarlyView.
We describe use of a novel zero‐dose approach to tomographic volumetric additive manufacturing that has enabled us to print silicone micro‐ and millifluidic devices and instant molds within minutes. The silicones are polymerized using photoactivated dormant platinum photohydrosilylation catalysts that would traditionally be difficult to access in ...
Johanna A. Vandenbrande, Martin P. De Beer, Erika J. Fong, Aftab Bhanvadia, Massimiliano Ferrucci, Wilson Kong, Daniel Wang, Ryan M. Hensleigh, Michell Marufu, James S. Oakdale, Fangyou Xie, Maxim Shusteff, Johanna J. Schwartz   +12 more
wiley   +1 more source

A Cost-Effective IoT System for Monitoring Indoor Radon Gas Concentration

Italian National Conference on Sensors, 2018
Radon is a noble gas originating from the radioactive decay chain of uranium or thorium. Most radon emanates naturally from the soil and from some building materials, so it can be found in many places around the world, in particular in regions with soils
Óscar Blanco-Novoa, T. Fernández-Caramés, Paula Fraga-Lamas, L. Castedo   +3 more
semanticscholar   +1 more source

NAD+‐Dependent Enzyme SIRT3 Limits Intestinal Epithelial Cell Functions Through NAD+ Synthesis Pathway in Colorectal Cancer

Advanced Science, EarlyView.
Microbiota‐derived quinolinic acid is used as an alternative source of replenishing the intracellular NAD+ pool induced by SIRT3 deficiency to regulate intestinal epithelial cell and T cell function, which has implications for targeting intestinal epithelial cells as an approach to the treatment of immune‐associated diseases, including colorectal ...
Ruiying Niu, Yingjie Dong, Jianghui Tong, Jingxuan Xia, Longhao Zhao, Zi Geng, Yingxin Lin, Jinghe Zhang, Xinyi Liu, Manqi Fang, Xi Jin, Yujing Bi, Guangwei Liu   +12 more
wiley   +1 more source

Folic Acid‐Modified Ginger‐Derived Exosome‐Like Nanoparticles Co‐Delivering Sunitinib Suppress Renal Cell Carcinoma via PI3K‐Akt Pathway Inhibition, P‐gp Downregulation, and Macrophage Reprogramming

Advanced Science, EarlyView.
FPD‐GELNs co‐deliver Su and bioactive components. This active‐passive dual‐targeting strategy suppresses the progression of RCC through the following mechanisms: 1) inhibition of the PI3K‐Akt signaling pathway; 2) downregulation of ABCB1/P‐gp to enhance the chemosensitivity of RCC to Su; and 3) reprogramming of macrophages toward M1 polarization and ...
Haoyu Xu, Daixing Hu, Shixue Liu, Lei Yang, Junwu Li, Yuanyuan Bai, Guozhi Zhao, Wei Tang, Li Jiang   +8 more
wiley   +1 more source

MGM as a Large‐Scale Pretrained Foundation Model for Microbiome Analyses in Diverse Contexts

Advanced Science, EarlyView.
We present the Microbial General Model (MGM), a transformer‐based foundation model pretrained on over 260,000 microbiome samples. MGM learns contextualized microbial representations via self‐supervised language modeling, enabling robust transfer learning, cross‐regional generalization, keystone taxa discovery, and prompt‐guided generation of realistic,
Haohong Zhang, Yuli Zhang, Zixin Kang, Jiayun Xiong, Ronghua Yang, Kang Ning   +5 more
wiley   +1 more source

A Quantum Framework for Protein Binding‐Site Structure Prediction on Utility‐Level Quantum Processors

Advanced Science, EarlyView.
This study presents a hybrid quantum‐classical framework for accurate prediction of protein structures on utility‐level quantum processors. We evaluate the practical application of the Variational Quantum Eigen‐solver (VQE) in protein structure prediction and demonstrate its superiority over state‐of‐the‐art deep learning methods in molecular docking ...
Yuqi Zhang, Yuxin Yang, William Martin, Kingsten Lin, Zixu Wang, Cheng‐Chang Lu, Weiwen Jiang, Ruth Nussinov, Joseph Loscalzo, Qiang Guan, Feixiong Cheng   +10 more
wiley   +1 more source

Inversion Formula for a Radon-Type Transform Arising in Photoacoustic Tomography with Circular Integrating Detectors

Advances in Mathematical Physics, 2018
This paper is devoted to a Radon-type transform arising in a version of Photoacoustic Tomography that uses integrating circular detectors. The Radon-type transform that arises can be decomposed into the known Radon-type transforms: the spherical Radon ...
Sunghwan Moon
doaj   +1 more source