Results 141 to 150 of about 272,002 (348)

Aberrant Mitochondrial Metabolism in Alzheimer's Disease Links Energy Stress with Ferroptosis

open access: yesAdvanced Science, EarlyView.
Alves et al. reveal how energy loss and oxidative stress, two major features of Alzheimer's disease, are connected. Mitochondria controls the flux of the antioxidant glutathione (GSH), via facilitating both its production and consumption. Energy restriction limits GSH synthesis, conferring vulnerability to cell death by ferroptosis, implicated as a ...
Francesca Alves   +17 more
wiley   +1 more source

Calculated Forces during Cross-Cutting of Rafting Bundles in Coastal Warehouse Conditions

open access: yesЛесной журнал
For long distances of round timber delivery, transport in rafts is often the only economically viable option. The bank bundling of logs predominates.
Sergey V. Posypanov   +2 more
doaj   +1 more source

Atypical protein kinase C (PKCzeta/lambda) is a convergent downstream target of the insulin-stimulated phosphatidylinositol 3-kinase and TC10 signaling pathways. [PDF]

open access: yes, 2004
Insulin stimulation of adipocytes resulted in the recruitment of atypical PKC (PKCzeta/lambda) to plasma membrane lipid raft microdomains. This redistribution of PKCzeta/lambda was prevented by Clostridium difficile toxin B and by cholesterol depletion ...
Hwang, Joseph B   +4 more
core   +1 more source

Microwave‐Activated Bacterial Biorobot for Multimodal Cancer Therapy

open access: yesAdvanced Science, EarlyView.
An Escherichia coli bacterial biorobot is engineered for localized microwave activation in cancer therapy. Upon activation at tumor sites, the biorobot releases glucose oxidase, inducing tumor cell death via glucose depletion and H2O2 generation catalyzed by Cu2O.
Huilan Zhuang   +9 more
wiley   +1 more source

Inhalable Artificial Polymeric Nucleases Degrading Neutrophil Extracellular Trap‐DNAs and Alleviating Pulmonary Fibrosis

open access: yesAdvanced Science, EarlyView.
Pulmonary fibrosis (PF) is promoted by NETs that induce fibroblast activation. PEG‐PIm, a polymeric artificial DNase is reported that efficiently degrades NET‐DNA via phosphodiester bond hydrolysis. Inhalation of PEG‐PIm in a mouse PF model prevents fibroblast activation and fibrosis progression, offering a promising therapeutic strategy for NET ...
Yibo Du   +7 more
wiley   +1 more source

Synthesis of novel glycopolymer brushes via a combination of RAFT-mediated polymerisation and ATRP

open access: yesSouth African Journal of Science, 2011
Glycopolymers (synthetic sugar-containing polymers) have become increasingly attractive to polymer chemists because of their role as biomimetic analogues and their potential for commercial applications.
Reda Fleet   +2 more
doaj  

Lead Halide Perovskite Nanocrystals in Metal‐Organic Frameworks: Synthesis, Properties, and Applications

open access: yesAdvanced Science, EarlyView.
Perovskites, when applied in devices, face challenges like stability. Integrating halide perovskites into metal‐organic frameworks (MOFs) as composites has gained attention. This approach can enhance stability, facilitate electron transport, and improve crystallinity, thus boosting perovskite performance in various applications.
Xiaochen Fang   +8 more
wiley   +1 more source

Oyster Reef Restoration Project for the City of Dover, Grizzle [PDF]

open access: yes, 2006
This project was conducted as a contract between the City of Dover and the University of New Hampshire, with additional funding supplied by the New Hampshire Estuaries Project.
Abeels, Holly   +2 more
core   +2 more sources

Home - About - Disclaimer - Privacy