Results 71 to 80 of about 498,772 (347)

Selfvergifnis – ’n Afgeskeepte area binne die pastoraat

In die Skriflig, 2020
Self-forgiveness – A neglected area within the pastorate: The scientific study of the theme of forgiveness in general, has only begun to gain momentum during the 1970s – it is thus a relatively new concept within the helping professions.
Wentzel C. Coetzer
doaj   +1 more source

RAGE Architecture for Reusable Serious Gaming Technology Components [PDF]

, 2016
For seizing the potential of serious games, the RAGE project - funded by the Horizon-2020 Programme of the European Commission - will make available an interoperable set of advanced technology components (software assets) that support game studios at ...
Georgiev, Atanas, Martinez Ortiz, Ivan, Nyamsuren, Enkhbold, Van der Vegt, Wim, Westera, Wim   +4 more
core   +5 more sources

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Post-translational modifications of beta-amyloid alter its transport in the blood-brain barrier in vitro model

Frontiers in Molecular Neuroscience
One of the hallmarks of Alzheimer's disease (AD) is the accumulation of beta-amyloid peptide (Aβ) leading to formation of soluble neurotoxic Aβ oligomers and insoluble amyloid plaques in various parts of the brain.
Kseniya B. Varshavskaya, Irina Yu Petrushanko, Vladimir A. Mitkevich, Evgeny P. Barykin, Alexander A. Makarov   +4 more
doaj   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

Rage Against the Machines: How Subjects Learn to Play Against Computers [PDF]

, 2005
We use an experiment to explore how subjects learn to play against computers which are programmed to follow one of a number of standard learning algorithms.
Dürsch, Peter, Kolb, Albert, Oechssler, Jörg, Schipper, Burkhard C.   +3 more
core   +6 more sources

Physician‐Scientist Pipeline for Pediatric Rheumatology: The Current Landscape and Future Perspectives

Arthritis Care &Research, EarlyView.
Over the past 50 years, the science of pediatric rheumatology has grown exponentially due to an expansion in the understanding of complex rheumatic conditions and a surge in novel targeted therapeutics. Physician‐scientists in the field of pediatric rheumatology have played major roles in these advancements that have improved the care of children ...
Ekemini A. Ogbu, Linda T. Hiraki, Mara L. Becker   +2 more
wiley   +1 more source

Connaissances, attitudes, pratiques des chefs de ménage et facteurs associés, en matière de rage, région de la Kara, Togo, 2019

Journal of Interventional Epidemiology and Public Health
Introduction: Au Togo, le nombre de cas de morsures de chien a doublé de 2016 à 2018 passant de 10 cas en 2016 à 16 cas en 2017 et 21 cas en 2018. La région de la Kara enregistre les plus grands effectifs de cas et de décès liés à la rage déclarée. Cette
Abdou-Rahim Ouro-Koura, Rébecca Kinde, Koffi Akolly, Tsidi Agbéko Tamekloe, Kokouvi Ade Hyacinthe Adoun, Koffi Amouzou, Possowa Gnansa Papissi, Ahodo-Abalo Koye, Gnandja Kodougou, Kokou Missiamenou, Sibabé Agoro, Logte Gountaanthe Sanwogou, Richard Midokpo, Koumavi Ekouevi   +13 more
doaj   +1 more source

Carboxylic‐Acid Functionalized Multiwalled Carbon Nanotube‐Alkane‐Based Resistive Temperature Sensor for Cold Chain Applications

Advanced Engineering Materials, EarlyView.
This study presents a reversible temperature sensor with high switching ratio, ∼103. The device is fabricated using PET‐ITO and carbon nanotube dispersions in alkane. Considering its application in cold chain logistics, a proof‐of‐concept with LED is showcased. Thus, a temperature drop below the threshold temperature (crystallization temperature of the
Sunil Kumar Behera, Philippe Marrec, A. Jorge Parola, Madalena Dionísio, Hugo Águas, Andreia F. M. Santos, Hamed Pourkheirollah, Donald Lupo, César A. T. Laia   +8 more
wiley   +1 more source