Human frataxin deficiency causes Friedreich's ataxia, yet how iron‐binding events are communicated across the protein is unclear. Using transfer entropy analysis of molecular dynamics simulations, we identify buried hydrophobic core leucines (LEU136, LEU140) as the source of directional signaling toward the iron‐binding acidic ridge.
Kevser Kübra Kırboğa +1 more
wiley +1 more source
Constrictions and shear stress are key determinants of amyloidogenic light chain (AL) amyloidosis
In this study, we investigate how flow constrictions and shear stress trigger cardiac antibody light chain (AL) fibril formation and deposition. We mimic the mechanical forces exerted by the heart and the microvasculature network using a mini‐peristaltic pump setup and a grid‐type microchannel network, respectively.
Yuji Goto +11 more
wiley +1 more source
ABSTRACT Changes in angling response were studied over a period of three years in a natural, previously unfished population of northern pike. Standardized angling sessions took place during two weeks in spring and autumn with three bait types: bright‐ and natural‐colored soft plastic baits and a dead baitfish.
Jorrit Lucas +3 more
wiley +1 more source
Visual, vestibular, and ocular motor changes during nitroglycerin‐triggered vestibular migraine
Plain Language Summary Vestibular migraine (VM) is a common cause of intermittent dizziness, but there have been no studies with provoked (induced) VM used to characterize how the vestibular and ocular (vision) systems interact. We injected 20 patients with VM with nitroglycerin to provoke an attack and used a specialized camera to record their eye ...
Maria Dolores Villar‐Martinez +4 more
wiley +1 more source
Playing the Children Card in the Game of European Integration
Abstract This article analyses the European Union (EU) Proposal on the mutual recognition of parenthood as a case to examine the dynamics of European integration in highly politicised domains such as family law, same‐sex parenthood and surrogacy, where the Union has limited formal competences.
Víctor Hugo Ramírez García
wiley +1 more source
Abstract There is a growing interest in Atlantic salmon (Salmo salar) aquaculture to extend the time fish are reared in freshwater (FW) recirculating aquaculture systems (RAS), producing larger FW salmon that can then be induced to undergo smoltification before transfer into marine net pens for grow‐out and harvest.
Le Thi Hong Gam +5 more
wiley +1 more source
Abstract Triploidy is an effective tool for producing sterile fishes but often results in impaired performance in commercial aquaculture. In light of this, our study compared the physiological response to exhaustive exercise in juvenile diploid and triploid Arctic charr Salvelinus alpinus, a polar species with great potential for aquaculture.
John D. Clark, Tillmann J. Benfey
wiley +1 more source
Energetics of the Citric Acid Cycle in the Deep Biosphere
This book is Open Access. A digital copy can be downloaded for free from Wiley Online Library.
Explores the behavior of carbon in minerals, melts, and fluids under extreme conditions
Carbon trapped in diamonds and carbonate-bearing rocks in subduction zones are examples of the continuing exchange of substantial carbon ...
Peter A. Canovas III, Everett L. Shock
wiley +1 more source
Follicular development during the follicular phase of the menstrual cycle: the enigma of luteinizing hormone receptor function. [PDF]
Yding Andersen C +3 more
europepmc +1 more source
Abstract Many Arctic fishes experience prolonged periods of extreme cold and large thermal variation over both rapid and seasonal time scales which challenge critical physiological functions. In the central Canadian Arctic, we caught wild adult lake trout (Salvelinus namaycush) acclimatized to winter and summer temperatures to determine the extent to ...
Emily P. Williams +6 more
wiley +1 more source

