Results 191 to 200 of about 114,858 (292)

Crystal structure of plant γ‐glutamyl peptidase 1: implications for sulfur metabolism and secondary metabolite biosynthesis

The FEBS Journal, Volume 293, Issue 5, Page 1400-1414, March 2026.
The crystal structures of Arabidopsis thaliana γ‐glutamyl peptidase 1 (GGP1), including the covalent intermediate state, were determined. GGP1 is involved in both glutathione degradation in the primary metabolism and glutathione conjugate processing in the secondary metabolism of glucosinolate and camalexin biosynthesis.
Kosei Sone, Takehiro Ito, Hibiki Sawada, Chihaya Yamada, Toma Kashima, Akimasa Miyanaga, Naoko Ohkama‐Ohtsu, Shinya Fushinobu   +7 more
wiley   +1 more source

Mushroom stem-based diets elicit region-specific shifts in rainbow trout gut microbiota. [PDF]

Sci Rep
Saromines CJ, Reinoso S, Ruiz A, Torrecillas S, Tello Martín ML, Pérez Clavijo M, Gisbert E.   +6 more
europepmc   +1 more source

Molecular basis of antibiotic sensing by the TetR family regulator CecR – a structural perspective

The FEBS Journal, Volume 293, Issue 6, Page 1801-1817, March 2026.
Escherichia coli CecR, a member of the TetR family regulators, senses selected antibiotics and activates the expression of a putative drug efflux pump. Although present in many pathogenic Enterobacteriales strains, CecR remains poorly characterized. We present the first CecR crystal structure, which reveals a unique tunnel‐like ligand‐binding cavity ...
Agnieszka J. Pietrzyk‐Brzezinska, Anna Koczurowska, Marta Orlikowska, Maciej Nielipinski, Dominika Nielipinska, Bartosz Sekula   +5 more
wiley   +1 more source

Transcriptional regulation of human NMNAT2: insights from 3D genome sequencing and bioinformatics

The FEBS Journal, Volume 293, Issue 5, Page 1433-1458, March 2026.
NMNAT2 is a valuable drug target, as low levels increase the risk of neurodegeneration. We employed 4C‐seq to identify NMNAT2 regulatory regions in the human genome, revealing distinct interactomes of the NMNAT2 promoter in undifferentiated and neuron‐like SH‐SY5Y cells. Additionally, we uncovered NMNAT2‐associated genes and transcription factors. This
Yu Chen Chang, Sen Yang, Minyoung Cho, Kwangsik Nho, José‐Manuel Baizabal, Hui‐Chen Lu   +5 more
wiley   +1 more source

Cellular responses in rainbow trout Oncorhynchus mykiss to experimental Anisakis simplex infection. [PDF]

Parasitol Res
Kumas K, Dezfuli BS, Franchella E, Duan Y, Kania PW, Buchmann K.   +5 more
europepmc   +1 more source

Conditional deletion of the multiple sclerosis susceptibility gene ATXN1 identifies cell‐autonomous effects in the B‐cell compartment

The FEBS Journal, Volume 293, Issue 5, Page 1459-1477, March 2026.
Ataxin‐1 is a polyglutamine protein associated with the etiology of spinocerebellar ataxia type 1 (SCA1) that has been recently found implicated in the risk of developing the autoimmune disorder multiple sclerosis (MS). Here, we took a conditional knockout approach to ablate ataxin‐1 exclusively in the B‐cell compartment and we found that this protein ...
Jonathan Jacob Carver, Rachael Riley Denbrock, Cindy Carolina Martines, Alessandro Didonna   +3 more
wiley   +1 more source

Dietary Methionine Supplementation Improves Rainbow Trout (Oncorhynchus mykiss) Immune Responses Against Viral Haemorrhagic Septicaemia Virus (VHSV). [PDF]

Biology (Basel)
Vaz M, Themudo GE, Carvalho I, Schöninger FB, Tafalla C, Díaz-Rosales P, Costas B, Machado M.   +7 more
europepmc   +1 more source

Co‐localization of tau and TDP‐43 after extracellular vesicle delivery to cells

The FEBS Journal, Volume 293, Issue 5, Page 1495-1515, March 2026.
Extracellular vesicles (EVs) derived from donor cells transfected with EGFP–2N4R‐tau or mCherry‐wtTDP‐43 were taken up by recipient cells, leading to cytosolic co‐localization of tau and TDP‐43. Molecular modeling revealed that tau and TDP‐43 directly interact through hydrogen bonding, suggesting a mechanistic link underlying their co‐pathology ...
Farhang Aliakbari, Kathryn Volkening, Zahra Nayeri, Aysegul Yucel Polat, Neil Donison, Jacqueline Palik, Michael J. Strong   +6 more
wiley   +1 more source

Evaluating anaesthetic impacts on rainbow trout mucus biomarkers: towards sustainable aquatic animal welfare. [PDF]

Fish Physiol Biochem
Tejero M, Fernandez-Alacid L, Sanahuja I, Vallejo-Castaño A, Balsalobre C, Madrid C, Ibarz A.   +6 more
europepmc   +1 more source

Viral Disease Histopathology in Aquaculture Finfish: Organ‐Specific Pathological Changes and Diagnostic Insights, Referencing the World Organisation for Animal Health: A Review

Reviews in Aquaculture, Volume 18, Issue 2, March 2026.
ABSTRACT The aquaculture industry faces significant challenges from viral diseases, many of which are listed by the World Organisation for Animal Health (WOAH) as priority pathogens due to their impact on global finfish health and production. This review synthesizes current knowledge on the histopathology of key WOAH‐listed viral pathogens, including ...
Ram Babu Kurapati, Grace Ramena, Humphrey Wanjala, Sharon Gudapati, Yathish Ramena   +4 more
wiley   +1 more source