Results 251 to 260 of about 134,449 (350)

A steric gate prevents mutagenic dATP incorporation opposite 8‐oxo‐deoxyguanosine in mitochondrial DNA polymerases

open access: yesThe FEBS Journal, Volume 292, Issue 13, Page 3430-3448, July 2025.
Reactive oxygen species induce mutagenic DNA lesions, such as 8‐oxo‐2′‐deoxyguanosine (8‐oxodG), which acts as a template for dCMP and dAMP incorporation through its anti and syn conformations. Specific residues must regulate the fidelity of templated 8‐oxodG.
Noe Baruch‐Torres   +10 more
wiley   +1 more source

An adamantane‐based ligand as a novel chemical tool for thermosensory TRPM8 channel therapeutic modulation

open access: yesThe FEBS Journal, Volume 292, Issue 13, Page 3449-3476, July 2025.
Transient receptor potential cation channel subfamily M member 8 (TRPM8) is a cationic thermosensory channel crucial for cold sensation and menthol response. TRPM8 dysfunction leads to sensory symptoms such as cold allodynia. Targeting TRPM8 is important for treating diseases like peripheral neuropathies and cancer.
Angela Lamberti   +9 more
wiley   +1 more source

Conditioning of Rainbow Trout (<i>Oncorhynchus mykiss</i>) Broodstock in a High-Altitude Recirculating Aquaculture System: First Spawning at 3000 m.a.s.l. in Northern Chile. [PDF]

open access: yesAnimals (Basel)
Pepe-Victoriano R   +7 more
europepmc   +1 more source

The N6‐methyladenosine reader IGF2BP3 promotes bladder cancer progression through enhancing HSP90AB1 expression

open access: yesThe FEBS Journal, Volume 292, Issue 13, Page 3477-3493, July 2025.
N6‐methyladenosine (m6A) is a frequently occurring RNA modification that has emerged as an important player in tumour development through post‐transcriptional gene regulation. In this study, we found that IGF2BP3 modulates HSP90AB1 expression in an m6A modification‐dependent manner, activating the PI3K/AKT‐signaling pathway, and thereby promoting the ...
Xiaoqing Chen   +10 more
wiley   +1 more source

Enhancing therapeutic efficacy through degradation of endogenous extracellular matrix in primary breast tumor spheroids

open access: yesThe FEBS Journal, Volume 292, Issue 13, Page 3494-3507, July 2025.
Solid tumors have a complex extracellular matrix (ECM) that can significantly affect tumor behavior and treatment response. Understanding the role of the ECM is therefore critical for understanding tumor biology and improving therapeutic responses. In this study, we isolated primary cells from a DMBA‐induced tumor mass to generate three‐dimensional ...
Alessandra Lo Cicero   +6 more
wiley   +1 more source

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