Results 261 to 270 of about 134,449 (350)

Potency of agarose gel‐supported lipid bilayers for electrophysiologic analysis of channel pores formed by Bacillus thuringiensis insecticidal proteins

open access: yesThe FEBS Journal, Volume 292, Issue 13, Page 3508-3520, July 2025.
Agarose gel‐supported lipid bilayers constructed at the interface between the lipid solution and the recording solution are useful for measuring channel currents through different types of toxin pores. In this system, the lipid bilayers can be easily reconstructed even after the bilayer is disrupted, and measurements of toxin pores could be repeated ...
Tsubasa Okuda   +5 more
wiley   +1 more source

Natural aminosterols inhibit NMDA receptors with low nanomolar potency

open access: yesThe FEBS Journal, Volume 292, Issue 13, Page 3521-3544, July 2025.
Misfunction of N‐methyl‐D‐aspartate (NMDA) receptors is associated with many brain disorders, making them primary targets for drug discovery. Trodusquemine and other natural aminosterols inhibit NMDA receptors with low nanomolar potency through binding to the cell membranes followed by interaction with the channels.
Giulia Fani   +9 more
wiley   +1 more source

The complete absence of cytoplasmic γ‐actin results in no discernible phenotype in mice or primary fibroblasts

open access: yesThe FEBS Journal, Volume 292, Issue 13, Page 3565-3576, July 2025.
Mice and mouse embryonic fibroblasts homozygous for an Actg1 allele edited to translate β‐actin instead of γ‐actin (Actg1‐coding beta) are devoid of γ‐actin protein. We demonstrate that these Actg1c‐b/c‐b mice present with no measurable phenotype in survival, body mass, activity, muscle contractility, or auditory function.
Lauren J. Sundby   +7 more
wiley   +1 more source

The Effects of Kynurenic Acid in Zebrafish Embryos and Adult Rainbow Trout. [PDF]

open access: yesBiomolecules
Marszalek-Grabska M   +6 more
europepmc   +1 more source

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