Results 271 to 280 of about 134,449 (350)

Molecular mechanism for transcriptional regulation of the parathyroid hormone gene by Epiprofin

open access: yesThe FEBS Journal, Volume 292, Issue 14, Page 3659-3675, July 2025.
The secretion of parathyroid hormone (PTH) from the chief cells in the parathyroid glands is regulated by the concentration of extracellular calcium. Epiprofin (Epfn) expression is induced by NFATc2 in response to elevated serum calcium, and Epfn negatively regulates PTH production.
Takashi Nakamura   +8 more
wiley   +1 more source

Applying Chitosan-Based Films Enriched with Borago officinalis Extract for Active and Green Packaging of Fresh Rainbow Trout Fillets. [PDF]

open access: yesFoods
Güngören A   +7 more
europepmc   +1 more source

Y12C mutation disrupts IMPDH cytoophidia and alters cancer metabolism

open access: yesThe FEBS Journal, Volume 292, Issue 14, Page 3676-3695, July 2025.
IMPDH, the rate‐limiting enzyme for de novo GTP synthesis, can form polymers and cytoophidia to enhance activity by reducing GTP inhibition. In this study, a Y12C mutation in IMPDH2 was introduced via ABEmax base‐editing in human cancer cell lines to disrupt IMPDH polymerisation.
Chia‐Chun Chang   +7 more
wiley   +1 more source

18S rRNA Metagenomic Analysis of Nodular Gill Disease in Swiss Rainbow Trout (Oncorhynchus mykiss). [PDF]

open access: yesJ Fish Dis
Wynne JW   +7 more
europepmc   +1 more source

Protein succinylome analysis identifies citrate synthase as a central regulator of osteoclast metabolic activity

open access: yesThe FEBS Journal, Volume 292, Issue 14, Page 3736-3754, July 2025.
RANKL treatment induces expression of the aconitate decarboxylase (ACOD1) in differentiating osteoclasts, which increases succinate levels. The initially high expression of ACOD1 decreases towards the end of differentiation when the levels of the desuccinylase SIRT5 increase. Succinylation of citrate synthase (CS) was detected exclusively in stimulated
Dayoung Yu   +7 more
wiley   +1 more source

Structural and functional insights into extreme thermal stability and activity of two GH12 domains of a multidomain glycosidase from a hyperthermophilic euryarchaeon

open access: yesThe FEBS Journal, Volume 292, Issue 14, Page 3771-3794, July 2025.
The multidomain glycosidase MDG from the hyperthermophilic euryarchaeon Thermococcus sp. contains five protein domains: three catalytic domains (GH5, GH12‐1, and GH12‐2) and two cellulose‐binding modules (CBM2). In this study, the GH12‐1 and GH12‐2 domains were individually purified and biochemically characterized.
Kseniya S. Zayulina   +11 more
wiley   +1 more source

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