Results 1 to 10 of about 1,039 (88)

A Facile Synthesis of Raltegravir Potassium—An HIV Integrase Inhibitor

Journal of Heterocyclic Chemistry, 2019
A facile, cost‐effective, and commercially viable synthesis of Raltegravir Potassium (1) has been developed from 2‐(1‐amino‐1‐methyl‐ethyl)‐N‐[(4‐fluorophenyl)methyl]‐1,6‐dihydro‐5‐hydroxy‐1‐methyl‐6‐oxo‐4‐pyrimidinecarboxamide (9) with high purity and in good yields.
Kishore Karumanchi, Ramadas Chavakula, Raghu Babu Korupolu   +2 more
exaly   +3 more sources

Biowaiver monograph for immediate-release solid oral dosage forms: Raltegravir potassium

Journal of Pharmaceutical Sciences
31373144The present monograph discusses the possibility of BCS-based biowaivers for immediate release pharmaceutical products containing raltegravir potassium, which is used to treat human immunodeficiency virus (HIV) infections.
Rodrigo Cristofoletti, Vinod P Shāh, Atsushi Kambayashi   +2 more
exaly   +4 more sources

A Polar Radical Pair Pathway To Assemble the Pyrimidinone Core of the HIV Integrase Inhibitor Raltegravir Potassium

Angewandte Chemie - International Edition, 2008
Philip J Pye, Yong-Li Zhong, Gavin O Jones   +2 more
exaly   +4 more sources

Biorelevant in vitro Tools and in silico Modeling to Assess pH-Dependent Drug-drug Interactions for Salts of Weak Acids: Case Example Potassium Raltegravir

Journal of Pharmaceutical Sciences, 2022
S.517-528Background: Early assessment of pH-dependent drug-drug-interactions (DDIs) for salts of poorly soluble weakly acidic compounds offers various advantages for patient safety, the pharmaceutical industry, and regulatory bodies.
Mann, J., Karlsson, E.M., Segregur, D., Moir, A., Dressman, J.   +4 more
core   +3 more sources

Raltegravir Potassium – Rufinamide

, 2018
exaly   +3 more sources

A Newfangled Synthesis of Integrase Inhibitor Drug Substance Raltegravir Potassium

Asian Journal of Chemistry, 2019
Raltegravir sodium synthesis was achieved from its one of the key starting materials with retro synthetic approach, in which without using its critical starting material chemically known as 5-methyl-1,3,4-oxadiazole-2-carbonyl chloride and which is more unstable during the synthesis of raltegravir potassium.
Vamsi Krishna Potluri, S. Venkat Rao, Ramesh Babu Potluri   +2 more
core   +2 more sources

Development of a Second-Generation, Highly Efficient Manufacturing Route for the HIV Integrase Inhibitor Raltegravir Potassium

Organic Process Research & Development, 2010
A manufacturing route for the synthesis of raltegravir potassium 1 was developed via a thermal rearrangement of amidoxime DMAD adducts 6 to construct the key, highly functionalized hydroxypyrimidin...
Yong-Li Zhong, Remy Angelaud, Danny E. Mancheno, Kevin M. Belyk, Peter E. Maligres, Ross A. Miller, Robert A. Reamer, Steven A. Weissman, Guy R. Humphrey, David Askin, Philip J. Pye   +10 more
core   +2 more sources

Raltegravir Potassium [PDF]

, 2020

core   +2 more sources

Synthesis of the HIV Integrase Inhibitor Raltegravir Potassium

Synfacts, 2011

core   +2 more sources

Real-World Characterization of the Portuguese Population Living with HIV who Initiated Raltegravir Based-Regimens: The REALITY Study

Acta Médica Portuguesa, 2022
Introduction: Although raltegravir has been available since 2007, data are lacking on the Portuguese population living with HIV who initiated this antiretroviral therapy.
Rosário Serrão, Kamal Mansinho, Fernando Maltez, Nuno Marques, Alexandre Carvalho, Rosário Pazos, Alexandra Zagalo, Josefina Mendez, Isabel Neves, Joaquim Oliveira, Patrícia Pacheco, Ricardo Correia de Abreu, Ana Cláudia Miranda, Paula Camacho, Laura Paixão, Joana Almeida   +15 more
doaj   +1 more source