Results 11 to 20 of about 1,058 (107)
Journal of Diabetes Investigation, Volume 14, Issue 3, Page 489-493, March 2023., 2023 Human immunodeficiency virus patients receiving antiretroviral therapy can develop immune‐inflammatory reconstitution syndrome. Type 1 diabetes is an autoimmune disease, but type 1 diabetes is rarely reported as immune‐inflammatory reconstitution syndrome.
Maho Taguchi +10 more
wiley +1 more source
Bioinorganic Chemistry and Applications, Volume 2023, Issue 1, 2023., 2023 In this paper, the novel Schiff base ligand containing quinoline moiety and its novel copper chelate complexes were successfully prepared. The catalytic activity of the final complex in the organic reaction such as synthesis of chiral benzimidazoles and anti‐HIV‐1 activity of Schiff base ligand and the products of this reaction were investigated.
Sabikeh G. Azimi +4 more
wiley +1 more source
Antiretroviral drug–drug interactions: A comparison of online drug interaction databases
Journal of Clinical Pharmacy and Therapeutics, Volume 47, Issue 10, Page 1720-1724, October 2022., 2022 Actual or Potential Drug–drug Interactions Identified. Abstract What is known and objective Antiretrovirals have a high drug interaction potential, which can lead to increased toxicity and/or decreased efficacy. Multiple databases are available to assess drug–drug interactions. The aim of our study was to compare interaction identification for commonly
Emily N. Drwiega +2 more
wiley +1 more source
Mitochondrial changes associated with viral infectious diseases in the paediatric population
Reviews in Medical Virology, Volume 31, Issue 6, November 2021., 2021 Summary Infectious diseases occur worldwide with great frequency in both adults and children, causing 350,000 deaths in 2017, according to the latest World Health Organization reports. Both infections and their treatments trigger mitochondrial interactions at multiple levels: (i) incorporation of damaged or mutated proteins into the complexes of the ...
Sonia Romero‐Cordero +4 more
wiley +1 more source
Drug‐drug interaction of atazanavir on UGT1A1‐mediated glucuronidation of molidustat in human
Basic &Clinical Pharmacology &Toxicology, Volume 128, Issue 3, Page 511-524, March 2021., 2021 Abstract Molidustat is an oral inhibitor of hypoxia‐inducible factor (HIF) prolyl‐hydroxylase enhancing the erythropoietin (EPO) response to HIF; it is in clinical development for the treatment of anaemia related to chronic kidney disease. The predominant role of glucuronidation for molidustat clearance (formation of N‐glucuronide metabolite M1) and ...
Dorina van der Mey +7 more
wiley +1 more source
Risk Assessment of Drug‐Induced Long QT Syndrome for Some COVID‐19 Repurposed Drugs
Clinical and Translational Science, Volume 14, Issue 1, Page 20-28, January 2021., 2021 The risk‐benefit ratio associated with the use of repurposed drugs to treat severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2)‐related infectious coronavirus disease 2019 (COVID‐19) is complicated because benefits are awaited, not proven. A thorough literature search was conducted to source information on the pharmacological properties of 5 ...
Veronique Michaud +6 more
wiley +1 more source
Oxidative Medicine and Cellular Longevity, Volume 2021, Issue 1, 2021., 2021 Highly active antiretroviral therapy (HAART) is used in HIV‐infected patients. Alongside the prolongation of patients’ life, adverse side effects associated with long‐term therapy are becoming an increasing problem. Therefore, optimizing of HAART is extremely important.
Agnieszka Matuszewska +24 more
wiley +1 more source
, 2022 Art. 105630Non-bioequivalent plasma concentration profiles among different dosage forms of the salt of raltegravir, a poorly soluble acidic drug, were investigated using biorelevant in vitro testing combined with the commercial in silico software, Simcyp®
Komasaka, T., Dressman, J.
core +1 more source
, 2016 Multiple sources of anticipated degradation and process impurities of raltegravir potassium drug substance observed during the laboratory optimization and later during its bulk synthesis are described in this article.
Gulabrao D. Patil (2053858) +8 more
core +2 more sources
Development of biorelevant media and dissolution tests for gastrointestinal disease states
, 2022 Standard biorelevant media reflect the average gastrointestinal (GI) physiology in healthy volunteers. The use of biorelevant media in in vitro experiments has become an important strategy to predict drug behaviour in vivo and is often combined with in
Šegregur, Domagoj
core +1 more source