Results 11 to 20 of about 477,894 (133)

Drug‐drug interaction of atazanavir on UGT1A1‐mediated glucuronidation of molidustat in human

Basic &Clinical Pharmacology &Toxicology, Volume 128, Issue 3, Page 511-524, March 2021., 2021
Abstract Molidustat is an oral inhibitor of hypoxia‐inducible factor (HIF) prolyl‐hydroxylase enhancing the erythropoietin (EPO) response to HIF; it is in clinical development for the treatment of anaemia related to chronic kidney disease. The predominant role of glucuronidation for molidustat clearance (formation of N‐glucuronide metabolite M1) and ...
Dorina van der Mey, Michael Gerisch, Natalia A. Jungmann, Andreas Kaiser, Kenichi Yoshikawa, Simone Schulz, Martin Radtke, Silvia Lentini   +7 more
wiley   +1 more source

Risk Assessment of Drug‐Induced Long QT Syndrome for Some COVID‐19 Repurposed Drugs

Clinical and Translational Science, Volume 14, Issue 1, Page 20-28, January 2021., 2021
The risk‐benefit ratio associated with the use of repurposed drugs to treat severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2)‐related infectious coronavirus disease 2019 (COVID‐19) is complicated because benefits are awaited, not proven. A thorough literature search was conducted to source information on the pharmacological properties of 5 ...
Veronique Michaud, Pamela Dow, Sweilem B. Al Rihani, Malavika Deodhar, Meghan Arwood, Brian Cicali, Jacques Turgeon   +6 more
wiley   +1 more source

Long‐Term Administration of Abacavir and Etravirine Impairs Semen Quality and Alters Redox System and Bone Metabolism in Growing Male Wistar Rats

Oxidative Medicine and Cellular Longevity, Volume 2021, Issue 1, 2021., 2021
Highly active antiretroviral therapy (HAART) is used in HIV‐infected patients. Alongside the prolongation of patients’ life, adverse side effects associated with long‐term therapy are becoming an increasing problem. Therefore, optimizing of HAART is extremely important.
Agnieszka Matuszewska, Beata Nowak, Wojciech Niżański, Maria Eberhardt, Kinga Domrazek, Anna Nikodem, Benita Wiatrak, Krzysztof Zduniak, Kamil Olejnik, Anna Merwid-Ląd, Tomasz Tomkalski, Diana Jędrzejuk, Ewa Szeląg, Marzenna Podhorska-Okołów, Aleksandra Piotrowska, Izabela Jęśkowiak, Agata Heinrich, Maria Rutkowska, Wojciech Dziewiszek, Tomasz Sozański, Joanna Kwiatkowska, Paulina Jawień, Marek Bolanowski, Adam Szeląg, Yi Fang   +24 more
wiley   +1 more source

Solid State Characterization and Miscibility of Raltegravir in Soluplus Using Solid Dispersion Technology

Indian Journal of Pharmaceutical Education and Research, 2023
Background: Raltegravir Potassium (RTGP), a BCS class II drug used in the treatment of HIV, has minimal solubility in the aqueous medium, resulting in poor bioavailability; Further, RTGP poor dissolution and limited solubility are also major factors ...
Dani Lakshman Yarlagadda, A. M. Nayak, K. Bhat   +2 more
semanticscholar   +1 more source

Efficacy, effectiveness, and safety of integrase inhibitors in the treatment of HIV/AIDS in patients with tuberculosis: systematic review and meta-analysis

Research, Society and Development, 2022
Integrase Inhibitors are a promising new class of antiretroviral.  However, studies of these drugs in tuberculosis (TB) and, HIV/aids coinfection are scarce.
N. Resende, L. Pantuzza, W. Carvalho, S. S. Miranda, Isabella Zuppo Laper, Adriano Max Moreira Reis   +5 more
semanticscholar   +1 more source

Negative-charge-storing mechanism of potassium-ion electrets used for vibration-powered generators: Microscopic study of a-SiO2 with and without potassium atoms [PDF]

Appl. Phys. Lett. 117, 193902 (2020), 2020
A potassium-ion electret, which is a key element of vibration-powered microelectromechanical generators, can store negative charge almost permanently. However, the mechanism by which this negative charge is stored is still unclear. We theoretically study the atomic and electronic structures of amorphous silica (a-SiO2) with and without potassium atoms ...
arxiv   +1 more source

Potassium Control of Plant Functions: Ecological and Agricultural Implications

Plants, 2021
Potassium, mostly as a cation (K+), together with calcium (Ca2+) are the most abundant inorganic chemicals in plant cellular media, but they are rarely discussed.
J. Sardans, J. Peñuelas
semanticscholar   +1 more source

Efficacy, effectiveness, and safety of integrase inhibitors in the treatment of HIV/AIDS in patients with tuberculosis: A systematic review and meta-analysis

, 2021
Aims: To evaluate the efficacy, effectiveness, and safety of integrase inhibitors in the treatment of HIV/AIDS in patients coinfected with tuberculosis (TB). Methods: Clinical trials or observational studies were included.
N. Resende, L. Pantuzza, W. Carvalho, S. Miranda, I. Zuppo, A. Reis   +5 more
semanticscholar   +1 more source

The FDA-Approved Antiviral Raltegravir Inhibits Fascin1-Dependent Invasion of Colorectal Tumor Cells In Vitro and In Vivo

Cancers, 2021
Simple Summary Colorectal cancer (CRC) is the third leading cause of cancer-related deaths worldwide. Serrated adenocarcinoma (SAC) has been recently recognized by the WHO as a histological CRC with bad prognosis.
Begoña Alburquerque-González, Á. Bernabé-García, Manuel Bernabé-García, J. Ruiz-Sanz, Fernando F. López-Calderón, L. Gonnelli, L. Banci, J. Peña-García, I. Luque, F. J. Nicolás, María Luisa Cayuela-Fuentes, E. Luchinat, H. Pérez‐Sánchez, S. Montoro-García, P. Conesa‐Zamora   +14 more
semanticscholar   +1 more source

Docking Studies on HIV Integrase Inhibitors Based On Potential Ligand Binding Sites [PDF]

International Journal on Bioinformatics & Biosciences, vol. 2, pp. 21-29, 2012, 2012
HIV integrase is a 32 kDa protein produced from the C-terminal portion of the Pol gene product, and is an attractive target for new anti-HIV drugs. Integrase is an enzyme produced by a retrovirus (such as HIV) that enables its genetic material to be integrated into the DNA of the infected cell.
arxiv   +1 more source