Primary antifungal prophylaxis for cryptococcal disease in HIV‐positive people [PDF]
, 2018 Background Cryptococcal disease remains one of the main causes of death in HIV‐positive people who have low cluster of differentiation 4 (CD4) cell counts.
Awotiwon, Ajibola A +4 more
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Quantifying the HIV-1 integrase inhibitor raltegravir in female genital tract secretions using high-performance liquid chromatography with ultraviolet detection [PDF]
, 2010 Understanding the pharmacokinetics of drugs in peripheral body compartments, such as the genital tract, is particularly important in the infectious diseases arena.
Kashuba, Angela D.M. +2 more
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Abstracts from the 8th Drug Hypersensitivity Meeting (DHM)
, 2018 Clinical and Translational Allergy, Volume 8, Issue S3, 21 August 2018.
wiley +1 more source
Digoxin reveals a functional connection between HIV-1 integration preference and T-cell activation [PDF]
, 2017 HIV-1 integrates more frequently into transcribed genes, however the biological significance of HIV-1 integration targeting has remained elusive. Using a selective high-throughput chemical screen, we discovered that the cardiac glycoside digoxin inhibits
Ancuta, Petronela +11 more
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HIV treatment outcomes in Uganda : the impact of baseline characteristics and variability in pharmacokinetics and pharmacogenetics of antiretroviral drugs [PDF]
, 2013 Guidelines specify criteria for initiation and monitoring of antiretroviral treatment (ART), including options for first line regimens. Immunological progress remains a widely used form of HIV/ART monitoring and efavirenz, a preferred first line ...
Nanzigu, Sarah
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A multisystem investigation of raltegravir association with intestinal tissue: implications for pre-exposure prophylaxis and eradication [PDF]
, 2014 ObjectivesRecent clinical data have suggested high raltegravir concentrations in gut tissue after oral administration, with implications for treatment and prevention. We have used in silico, in vitro, ex vivo and in vivo models to further investigate the
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Fluorspar to fluorochemicals upon low-temperature activation in water [PDF]
The dangerous chemical hydrogen fluoride sits at the apex of the fluorochemical industry, but the substantial hazards linked to its production under harsh conditions (above 300 degrees Celsius) and transport are typically contracted to specialists.
Gouverneur, Véronique +5 more
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A Comparative Study of Newly Developed HPLC-DAD and UHPLC-UV Assays for the Determination of Posaconazole in Bulk Powder and Suspension Dosage Form [PDF]
, 2014 Objective. To develop and compare HPLC-DAD and UHPLC-UV assays for the quantitation of posaconazole in bulk powder and suspension dosage form. Methods. Posaconazole linearity range was 5–50 μg/mL for both assays. For HPLC-DAD assay, samples were injected
Dalia A. Hamdy, Tarek S. Belal
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, 2012 Canadian Journal of Infectious Diseases and Medical Microbiology, Volume 23, Issue A, Page 4A-128A, 2012.
wiley +1 more source
Role of viral protein R in infection of human dendritic cells by primate lentiviruses [PDF]
, 2017 Viral protein R (Vpr) is an evolutionarily conserved but poorly understood protein encoded by all primate lentiviruses, including the lineages that gave rise to both human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2), the causative agents of ...
Miller, Caitlin Michelle
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