Results 61 to 70 of about 15,894 (297)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
An unramified real plane curve is a conic
Le Matematiche, 2000 See directly the article.
Johan Huisman
doaj
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Ramification a regime rythmique et anisophyllie chez les vegetaux superieurs
Lilloa, 2022 El autor estudia las relaciones que existen entre la anisofilía y los tipos bien conocidos de ramificación a “régimen rítmico” (ramification a régime rythmique).
P. Champagnat
doaj
On ramification structures for finite nilpotent groups
, 2019 We extend the characterization of abelian groups with ramification structures given by Garion and Penegini in [Beauville surfaces, moduli spaces and finite groups, Comm. Algebra, 2014] to finite nilpotent groups whose Sylow p-subgroups have a 'nice power
Gül Erdem, Şükran
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Upper Ramification Groups for Arbitrary Valuation Rings [PDF]
T. Saito established a ramification theory for ring extensions locally of complete intersection. We show that for a Henselian valuation ring $A$ with field of fractions $K$ and for a finite Galois extension $L$ of $K$, the integral closure $B$ of $A$ in $
Kato, Kazuya, Thatte, Vaidehee
core +1 more source
Journal of Oasis Agriculture and Sustainable DevelopmentLes résultats des travaux antérieurs sur la caractérisation des cultivars locaux du carthame, suscite d’être approfondie pour une meilleure connaissance de ce patrimoine génétique.
Aissa Tirichine +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
BMC Plant Biology, 2017 Background Inflorescences of wheat species, spikes, are characteristically unbranched and bear one sessile spikelet at a spike rachis node. Development of supernumerary spikelets (SSs) at rachis nodes or on the extended rachillas is abnormal.
Oxana B. Dobrovolskaya +6 more
doaj +1 more source