Results 101 to 110 of about 2,864,260 (309)
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Russian Journal of Earth SciencesThe features of the mineral and chemical composition (major elements) of the Vendian-Cambrian rocks of the Silimkun Formation (V-Є1sl), exposed on the western side of the Upper Kalar graben syncline in the southwest of the Aldan shield, are considered ...
Merenkova Sofia +6 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
eSamizdat, 2021 Italian translation of O chem govoriat rukopisi: analiz rannei redaktsii Leta gospodnia I. Shmeleva by Liudmila Surovova. Translated by Iris Karafillidis (University of Pisa).
Ljudmila Surovova
doaj
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
eSamizdat, 2021 Italian translation of Spetsifika bytovaniia tekstov v literature russkogo zarubezh’ia 1920-1930ch gg. by Dmitrii Nikolaev. Translated by Iris Karafillidis (University of Pisa).
Dmitrij Nikolaev
doaj
AI-RAN: Transforming RAN with AI-Driven Computing Infrastructure
IEEE Communications MagazineThe radio access network (RAN) landscape is undergoing a transformative shift from traditional, communication-centric infrastructures towards converged compute-communication platforms. This article introduces AI-RAN which integrates both RAN and artificial intelligence (AI) workloads on the same infrastructure.
Kundu, Lopamudra +4 more
openaire +2 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source