Results 91 to 100 of about 2,876,900 (319)

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Genetic polymorphism of gliadin-coding loci spelt (Triticum spelta L.) [PDF]

Selekcija i Semenarstvo, 2009
The polymorphism of 80 accessions Asian and European spelt gliadin-coding loci by one-dimensional PAAG-electrophoresis was studied. The important distinction to the alleles of gliadin loci of the European spelt (T. spelta L. ssp.
Brezhneva Tatyana A., Upelniek Vladimir Petrovič   +1 more
doaj  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Vendian-Cambrian Rocks of the Upper Kalar Graben-Syncline of the Southern Part of Siberian Craton: Mineralogy and Major Elements Geochemistry

Russian Journal of Earth Sciences
The features of the mineral and chemical composition (major elements) of the Vendian-Cambrian rocks of the Silimkun Formation (V-Є1sl), exposed on the western side of the Upper Kalar graben syncline in the southwest of the Aldan shield, are considered ...
Merenkova Sofia, Kuz'mina Tat'yana, Karpova Evgeniya Vladimirovna, Gabdullin Ruslan Rustemovich, Vodovozov Vladimir Yur'evich, Romashova Tat'yana Vladimirovna, Hohlova Irina Vladimirovna   +6 more
doaj   +1 more source

Di cosa parlano i manoscritti: un’analisi della prima redazione di “Leto gospodne” di I. Šmelëv (traduzione di Iris Karafillidis)

eSamizdat, 2021
Italian translation of O chem govoriat rukopisi: analiz rannei redaktsii Leta gospodnia I. Shmeleva by Liudmila Surovova. Translated by Iris Karafillidis (University of Pisa).
Ljudmila Surovova
doaj  

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

La specificità dei testi letterari della diaspora russa negli anni Venti e Trenta (traduzione di Iris Karafillidis)

eSamizdat, 2021
Italian translation of Spetsifika bytovaniia tekstov v literature russkogo zarubezh’ia 1920-1930ch gg. by Dmitrii Nikolaev. Translated by Iris Karafillidis (University of Pisa).
Dmitrij Nikolaev
doaj