Results 101 to 110 of about 644,781 (243)
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
TRANSITION TO INNOVATIVE ECONOMICS ON THE BASIS OF «ROAD CARD»: EXAMINATION, EVALUATION, PROSPECTS
Модернизация, инновация, развитие, 2016 The innovative economics model is examined in its interaction with the environment that includes such components as science, society, state, education, business and market as well as safety and court systems. Three main RF economics innovative and active
A. O. Baklanov +2 more
doaj
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Security Analysis and Implementation of Malicious Applications in 5G O-RAN Architecture
reservedIl progetto di tesi mira a studiare le vulnerabilità di sicurezza nell'architettura 5G O-RAN, con focus sulle xApp. Lo studio comprenderà l'approfondimento dell'ecosistema O-RAN e delle tecnologie associate (Docker, Kubernetes), seguito da un ...
BENEDETTI, DAVIDE
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FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source
Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region
FEBS Open Bio, EarlyView.Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson +2 more
wiley +1 more source
Palavras do Comandante da Academia Militar das Agulhas Negras
Revista Agulhas Negras, 2021 Paulo Roberto Rodrigues PIMENTEL
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Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
FEBS Open Bio, EarlyView.This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source
Avanços Tecnológicos para o Desempenho Físico do Soldado
Revista Agulhas Negras, 2023 Runer Augusto Marson +2 more
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Mitotic Control by Ran and RanBP1 in Mammalian Cells
, 2001 This chapter is an invited contribution to the book "The Small GTPase Ran", and describes the emerging roles of the RAN GTPase network, a signalling network implicated in many cellular functions, during cell division in human ...
Giulia Guarguaglini +2 more
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