Results 61 to 70 of about 2,876,900 (319)
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
UNH-RVAT 3-D Spalart--Allmaras RANS simulation results
, 2016 Peter Bachant, Martin Wosnik
+6 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Polymorphisms in MicroRNA Biogenesis Genes and the Risk of Preeclampsia in Jordan
Biomedical and Biotechnology Research JournalBackground: Preeclampsia (PE) is a serious pregnancy condition with a complex etiology involving both environmental and genetic factors. This study investigated the association between polymorphisms in the microRNA (miRNA) biogenesis genes DICER ...
Sahar Jawad Makhlouf +3 more
doaj +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Rudolf Buftmann se benadering tot die dag van die Here in 2 Petrus
HTS Teologiese Studies/Theological Studies, 1998 Rudolf Bnltmann,s programme of demythologizing applied to theconcept of the day of the Lord In 2 Peter. In order to grasp the meaning of the concept of the day of the Lord in 2 Peter for today 2 Peter is interpreted in terms of a specific historical ...
Gert Dreyer, Andries van Aarde
doaj +1 more source
, 2014 This paper tells the true story of a Hungarian refugee who\u27s family fled the communist regime there in 1971. Gabriella Bercze\u27s story reflects on what it was like to live in Hungary under communist rule, and her family\u27s experience in escaping ...
Bias, Sara R.
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