Results 61 to 70 of about 573,005 (298)

Towards juristocracy: the origins and consequences of the new constitutionalism

open access: yes, 2007
In countries and supranational entities around the globe, constitutional reform has transferred an unprecedented amount of power from representative institutions to judiciaries. The constitutionalization of rights and the establishment of judicial review
Hirschl, Ran
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

On the Automation of RAN Slicing Provisioning and Cell Planning in NG-RAN [PDF]

open access: yes2018 European Conference on Networks and Communications (EuCNC), 2018
Peer ...
Ferrús Ferré, Ramón Antonio   +3 more
openaire   +2 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

A joint backhaul and RAN perspective on the benefits of centralised RAN functions [PDF]

open access: yes2016 IEEE International Conference on Communications Workshops (ICC), 2016
Cloud-RAN (C-RAN) is considered a prime 5G enabler with promising resource pooling gains, tighter coordination among cells, and cost saving in remote radio heads and corresponding deployment and operation. However, C-RAN brings stringent requirements on the backhaul last mile, or the fronthaul, in terms of capacity, latency, and synchronisation, to the
Mona Jaber   +4 more
openaire   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Terrigenous Tertiary Gold Bearing Strata: World Distribution, Economic Significancy and Modern Placer Formation Capacity

open access: yesRussian Journal of Earth Sciences
The article is dedicated to estimation of tertiary terrigenous strata role in world gold mining. Localization peculiarities of tertiary gold deposits and their placers were examined.
Vladimirceva Ol'ga   +3 more
doaj   +1 more source

Polymorphisms in MicroRNA Biogenesis Genes and the Risk of Preeclampsia in Jordan

open access: yesBiomedical and Biotechnology Research Journal
Background: Preeclampsia (PE) is a serious pregnancy condition with a complex etiology involving both environmental and genetic factors. This study investigated the association between polymorphisms in the microRNA (miRNA) biogenesis genes DICER ...
Sahar Jawad Makhlouf   +3 more
doaj   +1 more source

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