Results 131 to 140 of about 30,329 (268)

Efficacy and Safety Assessment of 5‐Fluorouracil, Irinotecan and Oxaliplatin‐Loaded Implants in Mouse and Pig Models for Pancreatic Cancer Therapy

Advanced Materials, EarlyView.
A novel FIRINOX‐loaded implant demonstrates controlled drug release, and potent therapeutic efficacy in pancreatic ductal adenocarcinoma mouse models with safety confirmed in a large‐animal pre‐clinical model. This innovative drug delivery platform offers a promising new treatment approach for non‐resectable, treatment‐resistant pancreatic cancer ...
Samantha J. Wade, Ashna A. Kumar, Samuel O. Nitschke, Paul Joyce, Elahe Minaei, Stephanie E. Reuter, Chelsea Penney, Holly Warren, Ruby Shepherd, Jeremy N. Dinoro, Gordon G. Wallace, Anthony Dosseto, Sameera Ansar, Naila Islam, Alistair Lochhead, George Sharbeen, Phoebe A. Phillips, Morteza Aghmesheh, Wayne J. Hawthorne, Kara L. Vine‐Perrow   +19 more
wiley   +1 more source

Hierarchically Engineered Multi‐Enzyme Nanoreactors for in vitro Drug Biosynthesis and Pathway Transplantation Into Cells

Advanced Materials, EarlyView.
A hierarchically structured metal–organic framework (eMIL) is shown to host the complete six‐enzyme biosynthesis pathway for the anti‐cancer pigment violacein, reshaping reaction dynamics and multiplying in vitro yields. eMIL nanoreactors deliver this reconstituted bacterial multi‐protein system into mammalian cells, where cell‐derived substrates and ...
Ainur Sharip, Somayah S. Qutub, Manar M. Farooqui, Walaa Baslyman, Nida Khalfay, Lukman O. Alimi, Patricia Lopez Sanchez, Lingyun Zhao, Milena Chernyshevskaia, Giovanni Colombo, Niveen M. Khashab, Stefan T. Arold, Raik Grünberg   +12 more
wiley   +1 more source

Hydrogel‐Based 3D‐Printable Stretchable Pressure Sensor

Advanced Materials Technologies, EarlyView.
We present a carbon‐black‐functionalized double‐network granular hydrogel (DNGH) pressure sensor capable of detecting pressures from 200 Pa, equivalent to a light finger touch, up to 500 kPa. The sensor exhibits signal drifts below 3.5% after 800 cycles and response times around 80 ms. Leveraging this broad sensing range, we 3D print this material into
Tianyu Yuan, Chenzhuo Li, Antonia Georgopoulou, John M. Kolinski, Esther Amstad   +4 more
wiley   +1 more source

Optofluidic Raman Analysis and Capacity Recovery in Li‐ion Cells

Advanced Materials Technologies, EarlyView.
Operando Raman spectroscopy is used to monitor the degradation of commercial Li‐ion cells. Using a microfluidic access port, small amounts of electrolyte are sampled into a hollow‐core optical fibre, where fibre‐enhanced Raman analysis reveals Li+ solvation changes and solvent evolution.
Ermanno Miele, Wesley M. Dose, Ian A. K. Davidson, Hesham Sakr, Natalie V. Wheeler, Francesco Poletti, Michael De Volder, Clare P. Grey, Jeremy J. Baumberg, Tijmen G. Euser   +9 more
wiley   +1 more source

Recent Advances in Machine Learning for Network Automation in the O-RAN. [PDF]

Sensors (Basel), 2023
Hamdan MQ, Lee H, Triantafyllopoulou D, Borralho R, Kose A, Amiri E, Mulvey D, Yu W, Zitouni R, Pozza R, Hunt B, Bagheri H, Foh CH, Heliot F, Chen G, Xiao P, Wang N, Tafazolli R.   +17 more
europepmc   +1 more source

Direct Laser Writing of Magnetic Micro Actuators With a Stimulus‐Responsive Compliant Hinge

Advanced Materials Technologies, EarlyView.
This study presents a versatile modular design strategy for adaptive 3D microactuators. Using two‐photon‐induced C,H insertion reactions within solid polymer layers, chemically distinct hinge and stimulus responsive materials are patterned in one step. The hinge's properties enable tunable motion, mechanical control, and reconfigurable actuation across
Eleonora Galli, Nicolas Geid, Yizheng Liu, Friederike Strahl, Jürgen Rühe   +4 more
wiley   +1 more source

Additive‐Manufactured, Multifunctional Bioreactor Technology for Dynamic Culture of 3D Bioprinted Tissue Models

Advanced Materials Technologies, EarlyView.
We introduce an additively manufactured bioreactor with a perfusion flow system and integrated temperature and pH sensors for skeletal muscle tissue biofabrication. The bioreactor's performance was evaluated by assessing the viability, spreading of the myoblast cells in a printed scaffold, and contraction of the isolated murine musculi interossei ...
Lys Sprenger, Johann Schorzmann, Hsuan‐Heng Lu, Muhammad Osama, Julian Bauer, Michael Haug, Oliver Friedrich, Aldo R. Boccaccini, Frank Döpper, Sahar Salehi   +9 more
wiley   +1 more source

3D‐Printed Dynamic Heart Model With Left‐Side Anatomy and Integrated Sensor for Edge‐to‐Edge Repair and Regurgitation Reduction

Advanced Materials Technologies, EarlyView.
This work presents a fully synthetic, 3D‐printed dynamic heart model with left‐side anatomy featuring sutured mitral valve chordae tendineae analogs, embedded actuators for physiologic wall contraction, and customized flexible pressure sensors for the left ventricle.
Alejandro Guillen Obando, Hongyi Shen, Myles McGovern, Yusen Zhang, Vivien Lin, Darryl Fu, Ryan Baumwart, Kaiyan Qiu   +7 more
wiley   +1 more source

Fully 3D‐Printed Wave‐Wound Electromagnetic Motors

Advanced Materials Technologies, EarlyView.
This work presents the first fully 3D‐printed wave‐wound electromagnetic motors, which are created using conductive nanoparticle inks, carbon‐filled nylon polymers, and surface mount components. These motors can achieve a stall torque of 7.62N·mmA−1$7.62 \nobreakspace N{\cdot }mm A^{-1}$ and efficiency of 28.2 %, which approaches the performance of ...
Joseph Schwalbe, Sebastian Mettes, Eduardo Francke, Kenneth W. Allen, Yi Chen Mazumdar   +4 more
wiley   +1 more source

Grounding Large Language Models for Robot Task Planning Using Closed‐Loop State Feedback

Advanced Robotics Research, EarlyView.
BrainBody‐Large Language Model (LLM) introduces a hierarchical, feedback‐driven planning framework where two LLMs coordinate high‐level reasoning and low‐level control for robotic tasks. By grounding decisions in real‐time state feedback, it reduces hallucinations and improves task reliability.
Vineet Bhat, Ali Umut Kaypak, Prashanth Krishnamurthy, Ramesh Karri, Farshad Khorrami   +4 more
wiley   +1 more source