Results 131 to 140 of about 6,276,965 (319)
Advanced Science, EarlyView.This study presents the first telomere‐to‐telomere genomes and population resources for Diaporthe pathogens, uncovering the largest known fungal repertoire of secondary metabolite gene clusters. Structural variations and horizontal gene transfer drive cluster diversification, while specific rapidly evolving clusters control virulence, offering novel ...
Kainan Li +9 more
wiley +1 more source
The object allocation problem with random priorities
Games and Economic Behavior, 2018 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire +3 more sources
Regenerative Composition Structures
, 2003 A new class of random composition structures (the ordered analog of Kingman's partition structures) is defined by a regenerative description of component sizes.
Gnedin, Alexander, Pitman, Jim
core +2 more sources
Advanced Science, EarlyView.Mutant p53 drives oncogenic splicing to promote the progression of ovarian cancer by partnering with the spliceosome factor SNRPD2. Therefore, it is engineered iRGD‐exosomes to co‐deliver siRNAs against both targets. This approach restored tumor‐suppressive mRNA isoforms, effectively enhanced sensitivity to cisplatin, and ultimately blocked tumor ...
Wei Zhao +14 more
wiley +1 more source
Randomized Allocation of Treatments in Sequential Experiments
Journal of the Royal Statistical Society Series B: Statistical Methodology, 1981 Summary Since the idea of sequential allocation was first studied, in a version of what is now called the multi-armed bandit problem, the results of many investigations have shown that, even when an optimal allocation rule can be found, its form depends on the parameters of the model and no single rule has emerged that is widely ...
openaire +2 more sources
Advanced Science, EarlyView.During pupal metamorphosis and starvation, elevated 20‐hydroxyecdysone (20E) and suppressed insulin trigger Forkhead box O (FOXO) nuclear translocation, enhancing miR‐375‐3p expression. This downregulates fatty acid synthase (FASN) and Relish, promoting lipid breakdown for energy while prioritizing antioxidant responses over immune functions to support
Peng Chen +10 more
wiley +1 more source
ITGB1 Regulates Triple‐Negative Breast Cancer Development by Modulating the Tumor Microenvironment
Advanced Science, EarlyView.ABSTRACT Tumorigenesis and metastasis are frequently attributed to the intricate interplay between cancer cells and the tumor microenvironment (TME). Comprehending the mechanisms and key regulators of cancer‐immune crosstalk in the TME is imperative for developing efficacious immunotherapy.
Nuozi Song +12 more
wiley +1 more source
Advanced Science, EarlyView.T cell‐specific Socs1 knockout leads to inflammatory differentiation of CD8+ T cells, prompting the STAT1/2 complex to drive the activation of Ccl5, Ccr5, and Cxcr3, and promoting the skewing of monocytes toward a pro‐inflammatory M1 macrophage lineage.
Zhigui Wu +14 more
wiley +1 more source
TEAD1 Enhances Exosome Secretion and Promotes Exosome‐Mediated Tissue Regeneration
Advanced Science, EarlyView.TEAD1 functions as a crucial molecular switch regulating exosome secretion in various cell types. TEAD1 enhances exosome secretion by upregulating key proteins associated with exosome secretion, including RAB11, CD9, and SNAP23. This study reveals a novel role for TEAD1 in regulating exosome secretion and tissue regeneration, particularly in diabetic ...
Yan Pu +9 more
wiley +1 more source
A Natural Sweetener‐inducible Genetic Switch Controls Therapeutic Protein Expression in Mammals
Advanced Science, EarlyView.This study develops a natural sweetener, the psicose‐inducible transgene expression (PURE) system based on an Agrobacterium tumefaciens–derived transcriptional repressor PsiR. The PURE system is highly specific to psicose, being insensitive to other sugars and structurally similar molecules.
Longliang Qiao +16 more
wiley +1 more source