Results 231 to 240 of about 6,276,965 (319)

Systematic Engineering of Proteases in Saccharopolyspora Spinosa Reveals Synergistic Enhancement of Spinosad Biosynthesis via Substrate Flux Optimization

Advanced Science, EarlyView.
ARTP mutagenesis yielded Saccharopolyspora spinosa mutant D184 with improved extracellular nitrogen utilization. An integrated workflow of protease genetic manipulation, multi‐omics, and rational synergy design pinpointed a pepP‐clpP‐htpX synergistic triangular combination.
Duo Jin, Wangqiong Chen, Danlu Yang, Qing Liu, Baolong Bai, Zirui Dai, Xirong Liu, Zirong Zhu, Jie Rang, Liqiu Xia   +9 more
wiley   +1 more source

Intramedullary Fibular Nail Versus Plate Fixation for Adult Lateral Malleolus (Fibula) Fractures: A Systematic Review and Meta-Analysis. [PDF]

Cureus
Raufi MY, Hamsho W, Namjoshi K, Alnajjar M, Rhodes M, Bakhshayesh P.   +5 more
europepmc   +1 more source

Repeated Disuse Atrophy Imprints a Molecular Memory in Skeletal Muscle: Transcriptional Resilience in Young Adults and Susceptibility in Aged Muscle

Advanced Science, EarlyView.
Repeated disuse imprints a molecular memory in skeletal muscle, conferring transcriptional resilience in young adults but exaggerated susceptibility in aged muscle, driven by epigenetic regulation of aerobic metabolism, mitochondrial and NAD+ pathways.
Daniel C. Turner, Truls Raastad, Max Ullrich, Stian F. Christiansen, Hazel Sutherland, James Boot, Eva Wozniak, Charles Mein, Emilie Dalbram, Jonas T. Treebak, Daniel J. Owens, David C. Hughes, Sue C. Bodine, Jonathan C. Jarvis, Adam P. Sharples   +14 more
wiley   +1 more source

Energy-efficient framework based on optimal antenna selection in S-NOMA supported UAV IoT networks. [PDF]

PLoS One
Soni L, Taneja A, Alqahtani N, Alqahtani A.   +3 more
europepmc   +1 more source

Boosting Fast‐Charging Performance of Ni‐Rich NCM9055 Cathodes with Nb2O5 Dual Functional Modification

Advanced Science, EarlyView.
A dual‐functional Nb2O5 modulation strategy is reported to overcome kinetic limitations in Ni‐rich cathodes. The formation of LiNbO3 phase at the grain boundary of the polycrystalline NCM9055 cathode preserves a radially aligned microstructure and establishes fast lithium‐ion pathways.
Tian Rao, Zhaowen Bai, Jian Wang, Yang Ren, Qingsong Weng, Zhongzhu Liu, Maxim Avdeev, Robson Monteiro, Luanna Parreira, Xuejie Huang, Guohua Chen, Yongming Zhu   +11 more
wiley   +1 more source

Research on the Intelligent Allocation Method of Injection and Production Wellbores for Salt-Cavern Compressed Air Energy Storage under the Dual Constraints of Safety and Economy. [PDF]

ACS Omega
Ren Q, Wang J, Guan Y, Fu P, Song Z, Shi J.   +5 more
europepmc   +1 more source

Glucuronolactone Promotes Mucin Sulfation to Alleviate Deoxynivalenol‐Induced Intestinal Injury via Microbiota‐Dependent and ‐Independent AHR Activation

Advanced Science, EarlyView.
Glucuronolactone (GLU) as a natural metabolite of glucose, increases Lactobacillus amylovorus abundance and luminal IAA level to activate AHR signaling. In addition, GLU itself can directly elevate AHR signaling activity independently of microbiota and IAA.
Chenbin Cui, Beibei Zhang, Jiaxi Tang, Jing Hou, Yueqin Qiu, Kaiguo Gao, Li Wang, Zongyong Jiang, Xuefen Yang   +8 more
wiley   +1 more source

Collaborative optimization of computational offloading and resource allocation based on Stackelberg game. [PDF]

PLoS One
Li L, Yu Q, Wang C, Zhao J, Lv J, Wang S, Hu C.   +6 more
europepmc   +1 more source

Albumin‐Bound STING Agonist Reprograms HSPCs to Antitumor Neutrophils Enhancing CD8+ T Cell Immunity

Advanced Science, EarlyView.
This study demonstrates that an albumin‐bound STING agonist (Nano ZSA‐51D) reprograms HSPCs to produce antitumor neutrophils with enhanced MHC I–mediated CD8+ T cell activation, thereby sensitizing tumors to α‐PD1 therapy. These findings highlight a strategy to target early hematopoiesis for shaping neutrophil fate and potentiating cancer immunotherapy.
Jinsong Tao, Hong‐Yi Zhao, Chengyi Li, Hanning Wen, Fang Ke, Qiuxia Li, Miao He, Bo Wen, Zhongwei Liu, Kai Sun, Wei Gao, Duxin Sun   +11 more
wiley   +1 more source

Oral Health Intervention Strategies for Self-Caring Adults With Disabilities: A Systematic Review. [PDF]

Int J Dent
Sermsuti-Anuwat N, Hongpaitoon P, Ardiam D.   +2 more
europepmc   +1 more source