Results 61 to 70 of about 7,987 (267)

Random Boolean Networks and Attractors of their Intersecting Circuits [PDF]

2011 IEEE Workshops of International Conference on Advanced Information Networking and Applications, 2011
The multi-scale strategy in studying biological regulatory networks analysis is based on two level of analysis. The first level is structural and consists in examining the architecture of the interaction graph underlying the network and the second level is functional and analyse the regulatory properties of the network.
Demongeot, Jacques, Elena, Adrien, Noual, Mathilde, Sené, Sylvain   +3 more
openaire   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Attractors and time averages for random maps

Annales de l'Institut Henri Poincaré C, Analyse non linéaire, 2000
Considering random noise in finite dimensional parameterized families of diffeomorphisms of a compact finite dimensional boundaryless manifold M , we show the existence of time averages for almost every orbit of each point of M ...
openaire   +4 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Synchronization and Random Attractors in Reaction Jump Processes

Journal of Dynamics and Differential Equations
Abstract This work explores a synchronization-like phenomenon induced by common noise for continuous-time Markov jump processes given by chemical reaction networks. Based on Gillespie’s stochastic simulation algorithm, a corresponding random dynamical system is formulated in a two-step procedure, at first for the states of the embedded ...
Engel, M., Olicón-Méndez, G., Wehlitz, N., Winkelmann, S.   +3 more
openaire   +4 more sources

Strange Nonchaotic Attractors in Random Dynamical Systems [PDF]

Physical Review Letters, 2004
Whether strange nonchaotic attractors (SNAs) can occur typically in dynamical systems other than quasiperiodically driven systems has long been an open question. Here we show, based on a physical analysis and numerical evidence, that robust SNAs can be induced by small noise in autonomous discrete-time maps and in periodically driven continuous-time ...
Wang, X., Zhan, M., Lai, C.-H., Lai, Y.-C.   +3 more
openaire   +2 more sources

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

On random attractor of semilinear stochastically perturbed wave equation without uniqueness

Sistemnì Doslìdženâ ta Informacìjnì Tehnologìï, 2013
In this paper we investigate the dynamics of solutions of the semilinear wave equation, perturbed by additive white noise, in sense of the random attractor theory. The conditions on the parameters of the problem do not guarantee uniqueness of solution of
G. Iovane, O. V. Kapustyan, L. S. Paliichuk, O. V. Pereguda   +3 more
doaj  

Design and Analysis of a Quadratic Lorenz-like Attractor for Pseudo-Random Number Generation

Cumhuriyet Science Journal
This study introduces and analyzes a novel quadratic Lorenz-like attractor and demonstrates its application as a pseudo-random number generator (PRNG). A theoretical and numerical investigation of the system dynamics is conducted, including equilibrium ...
Bugce Eminaga Tatlicioglu, Hatice Aktöre   +1 more
doaj   +1 more source