Results 41 to 50 of about 841,294 (188)

Mode-Dependent Loss and Gain: Statistics and Effect on Mode-Division Multiplexing

, 2011
In multimode fiber transmission systems, mode-dependent loss and gain (collectively referred to as MDL) pose fundamental performance limitations. In the regime of strong mode coupling, the statistics of MDL (expressed in decibels or log power gain units)
Bellman, Benner, Bercovici, Berger, Chistyakov, Cohen, Dumitriu, Furstenberg, Glatarossa, Gloge, Gloge, Gordon, Ho, Ho, Hsu, Joseph M. Kahn, Kargin, Keang-Po Ho, Lu, Mecozzi, Nazarathy, Olshansky, Poole, Raddatz, Rosinski, Shah, Shemirani, Shentu, Shieh, Shieh, Stuart, Tao, Tarighat, Tarokh, Tong, Voiculescu, Wigner, Wu, Xie, Zhu, Zhu   +40 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

On Modeling Heterogeneous Wireless Networks Using Non-Poisson Point Processes

, 2015
Future wireless networks are required to support 1000 times higher data rate, than the current LTE standard. In order to meet the ever increasing demand, it is inevitable that, future wireless networks will have to develop seamless interconnection ...
Chun, Young Jin, Di Renzo, Marco, Ghrayeb, Ali, Hasna, Mazen Omar   +3 more
core   +1 more source

The stellar and sub-stellar IMF of simple and composite populations

, 2012
The current knowledge on the stellar IMF is documented. It appears to become top-heavy when the star-formation rate density surpasses about 0.1Msun/(yr pc^3) on a pc scale and it may become increasingly bottom-heavy with increasing metallicity and in ...
A Duquennoy, A Maeder, A Parravano, A Sollima, A Sollima, A Stolte, A Vazdekis, A Vazdekis, AA Muench, AE Piskunov, AJ Cenarro, AN Belikov, AP Whitworth, AR Boss, AS Eddington, AT Myers, B Binggeli, B García, B Reipurth, BG Elmegreen, BG Elmegreen, BG Elmegreen, BG Elmegreen, BG Elmegreen, BG Elmegreen, BG Elmegreen, BG Elmegreen, BG Elmegreen, C Briceño, C Esteban, C Flynn, C Grillo, C Hayashi, C Koen, C Low, C Reylé, C Soubiran, C Weidner, C Weidner, C Weidner, C Weidner, C Weidner, C Weidner, C Weidner, C Yasui, CA Tout, CJ Clarke, CJ Grillmair, CJ Lada, CJ Lonsdale, CL Slesnick, CM Baugh, CM Boily, D Calzetti, D Gouliermis, D Gouliermis, D Stamatellos, D Stamatellos, D Stamatellos, D Stamatellos, D Vanbeveren, DA Fischer, DA Forbes, DA Tilley, DA Tilley, DC Heggie, DF Figer, DJ Pinfield, DJ Price, DR Weisz, E Brocato, E Casuso, E Corbelli, E Moraux, E Schilbach, E Vesperini, E Vesperini, EA Evstigneeva, EA Hoversten, EE Salpeter, F D’Antona, F Egusa, F Motte, F Najarro, F Palla, F Paresce, F Selman, FC Adams, FC Adams, FD Kahn, G Basri, G Bosch, G Chabrier, G Chabrier, G Chabrier, G Chabrier, G Chabrier, G Chabrier, G Duchêne, G Garcia-Segura, G Garcia-Segura, G Marchi de, G Marchi de, G Marchi De, G Piotto, G Weigelt, G Wuchterl, G Wuchterl, GE Miller, GR Blumenthal, GR Meurer, H Bartko, H Baumgardt, H Baumgardt, H Bouy, H Jahreiss, H Kirk, H Sana, H Zinnecker, H Zinnecker, HT Janka, I Baraffe, I Misgeld, I Thies, I Thies, I Thies, I Thies, IA Bonnell, IA Bonnell, IA Bonnell, IA Bonnell, IA Bonnell, IA Bonnell, IN Reid, IN Reid, IN Reid, IN Reid, J Binney, J Bouvier, J Dabringhausen, J Dabringhausen, J Dabringhausen, J Jijina, J Köppen, J Maíz Apellániz, J Maíz Apellániz, J Maíz Apellániz, J Pflamm-Altenburg, J Pflamm-Altenburg, J Pflamm-Altenburg, J Pflamm-Altenburg, J Pflamm-Altenburg, J Pflamm-Altenburg, J Pflamm-Altenburg, J Pflamm-Altenburg, J Strader, JB Lamb, JC Tan, JD Neill, JE Dale, JE Gizis, JH Jeans, JJ Bochanski, JL Beuzit, JL Halbwachs, JM Kirk, JM Oliveira, JM Scalo, JN Bahcall, JP Anderson, JS Kalirai, JS Ulvestad, K Fuhrmann, K Kuijken, KD Finkelstein, KL Luhman, KL Luhman, KS Boer de, L Siess, L Testi, LA Hillenbrand, LA Hillenbrand, LJ Smith, LM Close, LR Penny, M Andersen, M Andersen, M Beech, M Dominik, M Fellhauer, M Fellhauer, M Fellhauer, M Fellhauer, M Fumagalli, M Haywood, M Mac Low, M Marks, M Marks, M Marks, M Marks, M Marks, M Marks, M Nagashima, M Ramspeck, M Schmalzl, M Schwarzschild, M Sirianni, MA Pérez-Torres, MG Wolfire, MJ Disney, MN Machida, MN Machida, MR Bate, MR Bate, MR Bate, MR Krumholz, MR Krumholz, MR Krumholz, MS Oey, MS Oey, N Bastian, N Ivanova, N Kevlahan, N Lodieu, N McCrady, N Moeckel, N Murray, N Phan-Bao, N Reid, N Rio Da, NC Hambly, NC Hambly, O Malkov, OY Malkov, P Girichidis, P Hennebelle, P Hennebelle, P Kroupa, P Kroupa, P Kroupa, P Kroupa, P Kroupa, P Kroupa, P Kroupa, P Kroupa, P Kroupa, P Kroupa, P Kroupa, P Kroupa, P Kroupa, P Kroupa, P Kroupa, P Kroupa, P Kroupa, P Massey, P Massey, P Padoan, P Padoan, P Wang, PA Crowther, PC Clark, PC Myers, PFL Maxted, PG Dokkum van, PG Dokkum van, PJE Peebles, PP Papadopoulos, PP Papadopoulos, PR Allen, R Chini, R Fuente Marcos de La, R Kudritzki, R Parra, R Wojtak, R Wünsch, RB Larson, RB Larson, RB Stothers, RC Kennicutt Jr, RJ Parker, RJ Parker, RJ Parker, RJ Smith, RJ White, RS Klessen, RS Klessen, RS Stobie, S Banerjee, S Basu, S Basu, S Bontemps, S Dib, S Dib, S Djorgovski, S Feltzing, S Hocuk, S Mieske, S Mieske, S Nayakshin, S Recchi, S Roychowdhury, S Röser, S Shen, S Zucker, SD Murray, SF Portegies Zwart, SJ Aarseth, SLW McMillan, SM Wilkins, SP Goodwin, SP Goodwin, SP Goodwin, SP Goodwin, SP Goodwin, SS Kim, SS Vogt, ST Megeath, T Chlebowski, T Hippel von, T Maschberger, T Maschberger, T Maschberger, T Onishi, T Peters, T Peters, T Preibisch, T Tsujimoto, TE Lutz, TJ Henry, TV Veltchev, U Löckmann, V Bromm, V Joergens, V Weidemann, VV Gvaramadze, VV Gvaramadze, W Jao, W-H Hsu, WJ Wit de, WJ Wit de, X Delfosse, X Delfosse, Y Li, Z-Y Li, Å Nordlund   +344 more
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Finite-size critical fluctuations in microscopic models of mode-coupling theory

, 2013
Facilitated spin models on random graphs provide an ideal microscopic realization of the mode-coupling theory of supercooled liquids: they undergo a purely dynamic glass transition with no thermodynamic singularity.
Franz, Silvio, Sellitto, Mauro
core   +3 more sources

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Stop memorizing: A data-dependent regularization framework for intrinsic pattern learning

, 2018
Deep neural networks (DNNs) typically have enough capacity to fit random data by brute force even when conventional data-dependent regularizations focusing on the geometry of the features are imposed.
Daubechies, Ingrid, Lu, Jianfeng, Qiu, Qiang, Sapiro, Guillermo, Wang, Bao, Zhu, Wei   +5 more
core