Results 51 to 60 of about 841,294 (188)

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

Error-proof programmable self-assembly of DNA-nanoparticle clusters

, 2007
We study theoretically a new generic scheme of programmable self-assembly of nanoparticles into clusters of desired geometry. The problem is motivated by the feasibility of highly selective DNA-mediated interactions between colloidal particles.
A. Y. Grosberg, Alexei V. Tkachenko, Nicholas A. Licata, P. de Gennes, R. A. L. Jones   +4 more
core   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Multidimensional Supernova Simulations with Approximative Neutrino Transport I. Neutron Star Kicks and the Anisotropy of Neutrino-Driven Explosions in Two Spatial Dimensions

, 2006
By means of two-dimensional (2D) simulations we study hydrodynamic instabilities during the first seconds of neutrino-driven supernova explosions, using a PPM hydrodynamics code, supplemented with a gray, non-equilibrium approximation of radial neutrino ...
Arras, Arras, Arzoumanian, Blondin, Blondin, Brisken, Bruenn, Buras, Buras, Burrows, Burrows, Burrows, Burrows, Burrows, Cen, Chatterjee, Chugai, Colella, Cordes, Cordes, Dorofeev, E. Müller, Einfeldt, Foglizzo, Foglizzo, Foglizzo, Freedman, Fryer, Fryer, Fryer, Fryer, Fryer, Fuller, H.-Th. Janka, Hansen, Herant, Herant, Herant, Hobbs, James, James, Janka, Janka, Janka, Janka, Johnston, K. Kifonidis, Keil, Khokhlov, Kifonidis, Kifonidis, Kotake, Kotake, L. Scheck, Lai, Lai, Lattimer, Leonard, Liebendörfer, Liebendörfer, Limongi, Livne, Lyne, Lüscher, Marek, Minerbo, Murphy, Myra, Müller, Müller, Ohnishi, Rampp, Rampp, Scheck, Schinder, Sehgal, Socrates, Thompson, Thompson, Thompson, Tubbs, Tubbs, Wang, Wang, Wang, Wang, Wheeler, Woosley, Woosley, Zou   +89 more
core   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

Nucleosynthesis-relevant conditions in neutrino-driven supernova outflows. II. The reverse shock in two-dimensional simulations

, 2010
After the initiation of the explosion of core-collapse supernovae, neutrinos emitted from the nascent neutron star drive a supersonic baryonic outflow.
A. Arcones, Arcones, Arnould, Blake, Buras, Buras, Burbidge, Burrows, Dessart, Duan, Duncan, Farouqi, Fischer, Freiburghaus, Fröhlich, H.-Th. Janka, Heger, Hoffman, Hüdepohl, Ishimaru, Janka, Janka, Janka, Kifonidis, Kratz, Kuroda, Lai, Liebendörfer, Marek, Meakin, Meakin, Metzger, Müller, Nordhaus, Otsuki, Panov, Pons, Pruet, Qian, Qian, Roberts, Scheck, Sneden, Sumiyoshi, Takahashi, Terasawa, Thompson, Wanajo, Wanajo, Wanajo, Wanajo, Witti, Wongwathanarat, Woosley, Woosley, Woosley, Young   +56 more
core   +1 more source

Biopsychosocial determinants of hand function and its trajectories over five years in patients with hand osteoarthritis

Arthritis Care &Research, Accepted Article.
Objectives This study aimed to investigate hand function trajectories over 5 years in primary hand osteoarthritis. Additionally, determinants of baseline and longitudinal hand function were assessed. Methods 538 patients with both baseline and 5‐year study visits were analyzed.
Annemiek V.E.M. Olde Meule, Coen van der Meulen, Jos Runhaar, Frits R. Rosendaal, Margreet Kloppenburg   +4 more
wiley   +1 more source

Adaptive Replication in Distributed Content Delivery Networks

, 2014
We address the problem of content replication in large distributed content delivery networks, composed of a data center assisted by many small servers with limited capabilities and located at the edge of the network.
Leconte, Mathieu, Lelarge, Marc, Massoulié, Laurent   +2 more
core   +1 more source

Prediction of Surface Topography Parameters in Direct Laser Interference Patterning of Stainless Steel Using Infrared Monitoring and Convolutional Neural Networks

Advanced Engineering Materials, EarlyView.
This study presents an infrared monitoring approach for direct laser interference patterning (DLIP) combined with a convolutional neural network (CNN). Thermal emission data captured during structuring are used to predict surface topography parameters.
Lukas Olawsky, Marcelo Sallese, Leander Kläber, Clemens Kuhn, Keming Du, Andrés Fabián Lasagni   +5 more
wiley   +1 more source

Evolution of Massive Black Hole Binaries

, 2003
We present the result of large-scale N-body simulations of the stellar-dynamical evolution of a massive black-hole binary at the center of a spherical galaxy.
Junichiro Makino, Makino J., Makino J., Makino J., Mikkola S., Okumura S. K., White S. D. M., Yoko Funato   +7 more
core   +2 more sources