Results 61 to 70 of about 31,463 (266)

Center manifolds for random dynamical systems with generalized trichotomies

Electronic Journal of Qualitative Theory of Differential Equations
In this paper, we consider small perturbations of linear Random Dynamical Systems evolving on a Banach space and admitting a general form of trichotomy.
António Bento, Helder Vilarinho
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Random Attractors for Stochastic Retarded Reaction-Diffusion Equations on Unbounded Domains

Abstract and Applied Analysis, 2013
This paper is devoted to a stochastic retarded reaction-diffusion equation on all d-dimensional space with additive white noise. We first show that the stochastic retarded reaction-diffusion equation generates a random dynamical system by transforming ...
Xiaoquan Ding, Jifa Jiang
doaj   +1 more source

Random attractors for stochastic two-compartment Gray-Scott equations with a multiplicative noise

Open Mathematics, 2016
In this paper, we consider the existence of a pullback attractor for the random dynamical system generated by stochastic two-compartment Gray-Scott equation for a multiplicative noise with the homogeneous Neumann boundary condition on a bounded domain of
Jia Xiaoyao, Gao Juanjuan, Ding Xiaoquan
doaj   +1 more source

Quasi-random dynamical systems [PDF]

Mathematical Notes of the Academy of Sciences of the USSR, 1969
This paper is the author's abstract of his dissertation for the degree Doctor of Physiomathematical Science. The dissertation was defended on March 7, 1969, in the Study of the Soviet Mechanical-Mathematical Faculty of the M. V. Lomonosov Moscow State University. Official opponents: Academician A. N. Kolmogorov, Dr. of Physicomathematical Sciences D. V.
openaire   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

The effect of quenched disorder on dynamical transitions in systems of coupled cells

New Journal of Physics, 2013
Non-equilibrium systems are characterized by a rich variety of dynamical behaviors, which may sensitively depend on control parameters. Here, we investigate and provide a quantitative analysis of the role of disorder on the transitions between different ...
Jinshan Xu, Rajeev Singh, Nicolas B Garnier, Sitabhra Sinha, Alain Pumir   +4 more
doaj   +1 more source