Results 61 to 70 of about 33,706 (264)
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
Random chain recurrent sets for random dynamical systems [PDF]
Dynamical Systems, 2009 It is known by the Conley's theorem that the chain recurrent set $CR(ϕ)$ of a deterministic flow $ϕ$ on a compact metric space is the complement of the union of sets $B(A)-A$, where $A$ varies over the collection of attractors and $B(A)$ is the basin of attraction of $A$.
Chen, X., Duan, J.
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Random Attractors for Stochastic Retarded Reaction-Diffusion Equations on Unbounded Domains
Abstract and Applied Analysis, 2013 This paper is devoted to a stochastic retarded reaction-diffusion equation on all d-dimensional space with additive white noise. We first show that the stochastic retarded reaction-diffusion equation generates a random dynamical system by transforming ...
Xiaoquan Ding, Jifa Jiang
doaj +1 more source
Random attractors for stochastic two-compartment Gray-Scott equations with a multiplicative noise
Open Mathematics, 2016 In this paper, we consider the existence of a pullback attractor for the random dynamical system generated by stochastic two-compartment Gray-Scott equation for a multiplicative noise with the homogeneous Neumann boundary condition on a bounded domain of
Jia Xiaoyao, Gao Juanjuan, Ding Xiaoquan
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Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
A SHADOWING LEMMA FOR RANDOM DYNAMICAL SYSTEMS
Journal of Applied Analysis & Computation, 2021 Summary: This paper proves a shadowing lemma for the random dynamical systems generated by a class of random parabolic equations. We propose random versions of Newton's method and solution-tracing theory to obtain our main theorem. This result applies to \(C^1\) random dynamical systems on Banach space without assuming the corresponding map to be a ...
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source