Results 61 to 70 of about 306,029 (281)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Theory of the Loschmidt echo and dynamical quantum phase transitions in disordered Fermi systems

Physical Review Research, 2023
In this work we develop the theory of the Loschmidt echo and dynamical phase transitions in noninteracting strongly disordered Fermi systems after a quench.
Tuomas I. Vanhala, Teemu Ojanen
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

On the Criticality of Adaptive Boolean Network Robots

Entropy, 2022
Systems poised at a dynamical critical regime, between order and disorder, have been shown capable of exhibiting complex dynamics that balance robustness to external perturbations and rich repertoires of responses to inputs.
Michele Braccini, Andrea Roli, Edoardo Barbieri, Stuart A. Kauffman   +3 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Random cyclic dynamical systems

Advances in Applied Mathematics, 2017
For X a finite subset of the circle and for 0 < r <= 1 fixed, consider the function f_r : X -> X which maps each point to the clockwise furthest element of X within angular distance less than 2 pi r. We study the discrete dynamical system on X generated by f_r, and especially its expected behavior when X is a large random set. We show that, as
Michał Adamaszek, Henry Adams, Francis Motta   +2 more
openaire   +3 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Conditional random matrix ensembles and the stability of dynamical systems

New Journal of Physics, 2015
Random matrix theory (RMT) has found applications throughout physics and applied mathematics, in subject areas as diverse as communications networks, population dynamics, neuroscience, and models of the banking system.
Paul Kirk, Delphine M Y Rolando, Adam L MacLean, Michael P H Stumpf   +3 more
doaj   +1 more source

Anomalous correlation-induced dynamical phase transitions

Scientific Reports, 2023
The nonanalyticity of the Loschmidt echo at critical times in quantum quenched systems is termed as the dynamical quantum phase transition, extending the notion of quantum criticality to a nonequilibrium scenario.
Niaz Ali Khan, Pei Wang, Munsif Jan, Gao Xianlong   +3 more
doaj   +1 more source

Random Dynamical Systems

, 2006
The concept of random dynamical system is a comparatively recent development combining ideas and methods from the well developed areas of probability theory and dynamical systems. Due to our inaccurate knowledge of the particular physical system or due to computational or theoretical limitations (lack of sufficient computational power, inefficient ...
openaire   +2 more sources