Results 101 to 110 of about 1,238,639 (328)
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Next‐generation proteomics improves lung cancer risk prediction
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Alzheimer's disease is a global health challenge, emphasizing the need for early detection to enable timely intervention and improve outcomes. This study analyzes handwriting data from individuals with and without Alzheimer's to identify predictive ...
Ngoc Truc Ngan Ho +2 more
doaj +1 more source
Research and Simulation of Queue Management Algorithms in Ad Hoc Networks Under DDoS Attack
Concentrating on the influence of DDoS applied to ad hoc networks, we introduced three classic queue management algorithms: Drop-Tail, random early detection (RED), and random exponential marking (REM). We analyzed and compared the defensive abilities of
Wei Wei +3 more
doaj +1 more source
Early Detection of Diabetes Using Random Forest Algorithm
Diabetes is one of the most chronic and deadly diseases. According to data from WHO in 2021, there were approximately 422 million adults living with diabetes worldwide, and this number is expected to continue to increase in the future due to various factors.
Cindy Nabila Noviyanti +1 more
openaire +1 more source
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Stunting remains a critical nutritional issue in Indonesia, significantly impacting the physical and cognitive development of children under five. Prompt and accurate detection of nutritional status is essential for early intervention. This study aims to
Shalsa Bela Dwi Widyawati +2 more
doaj +1 more source

