Results 121 to 130 of about 1,238,639 (328)

RED-SP-CoDel: Random early detection with static priority scheduling and controlled delay AQM in programmable data planes

, 2023
Osel Lhamo, Mingyu Ma, Tung V. Doan, Tobias Scheinert, Giang T. Nguyen, Martin Reisslein, Frank H. P. Fitzek   +6 more
openalex   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Multi‐modal machine learning for predicting amyloid positivity using on‐ramp driving

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION Early detection of amyloid p is critical for Alzheimer's disease (AD) risk identification. This study leverages machine learning of multi‐modal attributes, including vehicular, physiological, and demographic data, to classify older adults ...
Sai Santosh Reddy Danda, Yi Lu Murphey, Amanda Maher, Carol Persad, Savannah Rose, Robert Koeppe, Bruno Giordani   +6 more
doaj   +1 more source

A Novel Random Forest-SMOTE Framework With Polynomial Feature Engineering for Early Detection of Gastrointestinal Disorders

IEEE Access
About 40% of people around the world have gastrointestinal (GI) problems. Gastrointestinal issues negatively impact the lives of millions of people and place significant stress on healthcare systems.
Parvez Rahi, Mohammad Rashid Hussain, Salem Alqahtani, Mohammad Husain, Ajay Pal Singh, Inderjeet Singh   +5 more
doaj   +1 more source

New method for early detection of two random amplified polymorphic DNA (RAPD) groups of Staphylococcus aureus causing bovine mastitis infection in Paraná State, Brazil [PDF]

, 2010
Dicezar Gonçalves, Jane Eire Gabriel, Humberto Maciel França Madeira, G. S. e Schuhli, Vânia Aparecida Vicente   +4 more
openalex   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Comparative analysis of random forest and deep learning approaches for automated acute lymphoblastic leukemia detection using morphologicaland textural features

Jurnal Ilmiah Kursor: Menuju Solusi Teknologi Informasi
Acute Lymphoblastic Leukemia (ALL) is a type of blood cancer that requires early and accurate detection for effective treatment. Current diagnostic approaches face significant challenges including time-consuming manual examination, inter ...
Windra Swastika, Kestrilia Rega Prilianti, Paulus Lucky Tirma Irawan, Hendry Setiawan   +3 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source