Results 61 to 70 of about 1,238,639 (328)

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Random Early Detection Web Servers for Dynamic Load Balancing [PDF]

2009 10th International Symposium on Pervasive Systems, Algorithms, and Networks, 2009
Modern Web-server systems use multiple servers to handle an increased user demand. Such systems need effective methods to spread the load among web servers evenly in order to keep web server utilization high while providing sufficient quality of service for end users.
Chih-Chiang Yang, Chien Chen, Jing-Ying Chen   +2 more
openaire   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Imaging of Lung Structure Using Holographic Electromagnetic Induction

IEEE Access, 2017
Early lung cancer detection with suitable treatment can significantly reduce cancer-related death rates. This paper presents a single frequency holographic electromagnetic induction (HEI) imaging method for small lung tumor detection in human thorax ...
Lulu Wang, Ahmed M. Al-Jumaily
doaj   +1 more source

Protocol summary and statistical analysis plan for the randomized trial of early detection of clinically significant prostate cancer (ProScreen) [PDF]

, 2023
Jaakko Nevalainen, Jani Raitanen, Kari Natunen, Tuomas P. Kilpeläinen, Antti Rannikko, Teuvo L.J. Tammela, Anssi Auvinen, the ProScreen Trial Team   +7 more
openalex   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Performance Comparison of Multilayer Perceptron (MLP) and Random Forest for Early Detection of Cardiovascular Disease

Journal of Applied Informatics and Computing
Cardiovascular disease is a disorder of the heart and blood vessels that can lead to heart attacks, strokes, and heart failure, so early detection is essential.
Dita Widayanti Setiawan, Nouval Trezandy Lapatta, Amriana Amriana, Deny Wiria Nugraha, Chairunnisa Ar. Lamasitudju   +4 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source