Results 101 to 110 of about 4,395,518 (296)
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Effective aspects of Bernoulli randomness [PDF]
Journal of Logic and Computation, 2019 AbstractIn this paper, we study Bernoulli random sequences, i.e. sequences that are Martin-Löf random with respect to a Bernoulli measure $\mu _p$ for some $p\in [0,1]$, where we allow for the possibility that $p$ is noncomputable. We focus in particular on the case in which the underlying Bernoulli parameter $p$ is proper (i.e.
openaire +2 more sources
The Choice Between Fixed and Random Effects Models: Some Considerations for Educational Research [PDF]
We discuss fixed and random effects models in the context of educational research and set out the assumptions behind the two approaches. To illustrate the issues, we analyse the determinants of pupil achievement in primary school, using data from the ...
Clarke, Paul +3 more
core
Random Networks with Tunable Degree Distribution and Clustering
, 2004 We present an algorithm for generating random networks with arbitrary degree distribution and Clustering (frequency of triadic closure). We use this algorithm to generate networks with exponential, power law, and poisson degree distributions with ...
D. J. Watts +8 more
core +2 more sources
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Total Factor Productivity of Agricultural Firms in Vietnam and Its Relevant Determinants
Economies, 2019 In Vietnam, agriculture is a key sector that promotes economic growth and poverty reduction. Therefore, improving productivity in agriculture is indispensable to the sustainability of the country.
Mai Huong Giang +3 more
doaj +1 more source
Weakly disordered spin ladders
, 1997 We analyze an anisotropic spin 1/2 two legs ladder in the presence of various type of random perturbations. The generic phase diagram for the pure system, in a way similar to spin one chains, consists of four phases: an Antiferromagnet, a Haldane gap or ...
A. Luther +54 more
core +3 more sources
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
مجله اپیدمیولوژی ایران, 2018 Background and Objectives: Shift work as a pervasive phenomenon in various industrial sectors is one of the most stressful factors in the workplace.
F Zayeri, M Amini, H Hasanzadeh
doaj