A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento +3 more
wiley +1 more source
A hierarchical random effects state-space model for modeling brain activities from electroencephalogram data. [PDF]
Guo X, Yang B, Loh JM, Wang Q, Wang Y.
europepmc +1 more source
ABSTRACT Background X‐linked adrenoleukodystrophy (X‐ALD) is a neurometabolic disorder caused by pathogenic variants in ABCD1, leading to slowly progressive spinal cord disease in nearly all affected men. Sensitive biomarkers to quantify disease severity and predict progression are needed for clinical care and trial design.
Eda G. Kabak +4 more
wiley +1 more source
Diagnostic accuracy of 2D-SWE ultrasound for liver fibrosis assessment in MASLD: A multilevel random effects model meta-analysis. [PDF]
Indre MG +11 more
europepmc +1 more source
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio +8 more
wiley +1 more source
REDOMA: Bayesian random-effects dose-optimization meta-analysis using spike-and-slab priors. [PDF]
Yang CH, Kwiatkowski E, Lee JJ, Lin R.
europepmc +1 more source
Fixed-effect and random-effects models in meta-analysis. [PDF]
Zhai C, Guyatt G.
europepmc +1 more source
Maintaining the validity of inference from linear mixed models in stepped-wedge cluster randomized trials under misspecified random-effects structures. [PDF]
Ouyang Y, Taljaard M, Forbes AB, Li F.
europepmc +1 more source
Application of zero-inflated Poisson model with heterogeneous random effects to evaluate the effect of oral health education on pregnant women's dental caries: A longitudinal experimental study. [PDF]
Ahmadi Gooraji S +6 more
europepmc +1 more source

