Results 51 to 60 of about 4,395,518 (296)

Upacicalcet: A Novel Intravenous Calcimimetic Agent for Patients Undergoing Hemodialysis With Secondary Hyperparathyroidism

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving maintenance dialysis, driven by calcium and phosphate metabolism disturbances. Calcimimetics are central to the management of SHPT by enhancing calcium‐sensing receptor sensitivity and reducing parathyroid hormone secretion.
Fumihiko Koiwa   +3 more
wiley   +1 more source

On random-effects meta-analysis [PDF]

open access: yesBiometrika, 2015
Meta-analysis is widely used to compare and combine the results of multiple independent studies. To account for between-study heterogeneity, investigators often employ random-effects models, under which the effect sizes of interest are assumed to follow a normal distribution.
D. Zeng, D. Y. Lin
openaire   +3 more sources

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

open access: yesFEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Comparative Analysis of Tourism Determination in 36 Countries: A Panel Approach [PDF]

open access: yesAfrican Journal of Hospitality, Tourism and Leisure, 2019
This study utilizes panel estimation models to analyse the determinants of tourism in 36 countries with observations of 108, and countries are further disaggregated into sub-groupings of high income, upper middle income, low middle income and low income
Mr. N.S. Molepo* (PhD Candidate)   +2 more
doaj  

Recovering Crossed Random Effects in Mixed-Effects Models Using Model Averaging

open access: yesMethodology, 2022
Random effects contain crucial information to understand the variability of the processes under study in mixed-effects models with crossed random effects (MEMs-CR).
José Ángel Martínez-Huertas   +1 more
doaj   +1 more source

Increase in the random dopant induced threshold fluctuations and lowering in sub-100 nm MOSFETs due to quantum effects: a 3-D density-gradient simulation study [PDF]

open access: yes, 2001
In this paper, we present a detailed simulation study of the influence of quantum mechanical effects in the inversion layer on random dopant induced threshold voltage fluctuations and lowering in sub-100 mn MOSFETs.
Asenov, A   +4 more
core   +2 more sources

Mapping the evolution of mitochondrial complex I through structural variation

open access: yesFEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin   +2 more
wiley   +1 more source

Short and random: Modelling the effects of (proto-)neural elongations [PDF]

open access: yes, 2017
To understand how neurons and nervous systems first evolved, we need an account of the origins of neural elongations: Why did neural elongations (axons and dendrites) first originate, such that they could become the central component of both neurons and ...
de Wiljes, Oltman O.   +2 more
core   +3 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Metaan: Random-effects Meta-analysis [PDF]

open access: yesThe Stata Journal: Promoting communications on statistics and Stata, 2010
This article describes the new meta-analysis command metaan, which can be used to perform fixed- or random-effects meta-analysis. Besides the standard DerSimonian and Laird approach, metaan offers a wide choice of available models: maximum likelihood, profile likelihood, restricted maximum likelihood, and a permutation model.
Kontopantelis, Evangelos, Reeves, David
openaire   +2 more sources

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