Results 111 to 120 of about 5,148,982 (304)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Definition of necessary length of random sequences at execution of the empirical tests (criterion x2) [PDF]

open access: yesComputer Science Journal of Moldova, 1999
This article is devoted to the problem solution, arising from the necessity to test a sequence of random numbers. The application of Pearson's criterion imposes restriction from below on the number of elements of the random sequence.
O.M. Petrova
doaj  

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

Random model trees: an effective and scalable regression method [PDF]

open access: yes, 2010
We present and investigate ensembles of randomized model trees as a novel regression method. Such ensembles combine the scalability of tree-based methods with predictive performance rivaling the state of the art in numeric prediction.
Pfahringer, Bernhard
core  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

On the New Notion of the Set-Expectation for a Random Set of Events [PDF]

open access: yes
The paper introduces new notion for the set-valued mean set of a random set. The means are defined as families of sets that minimize mean distances to the random set.
Vorobyev, Oleg Yu., Vorobyev, Alexey O.
core  

Traditional and emerging techniques for practical random vibration analyses [PDF]

open access: yesFME Transactions, 2014
The paper focuses on available tools for conducting random vibration analyses for practical engineering problems. An inherent aspect of this theme is the simultaneous existence of elements with linear behavior, and of elements with nonlinear behavior ...
Spanos P.D.
doaj  

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

open access: yesMolecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both   +7 more
wiley   +1 more source

On Complete Convergence of the Sum of a Random Number of Stable Type P Random Elements

open access: yes, 2020
Complete convergence for randomly indexed normalized sums of random elements of the form [Formula Omitted] is established. The random elements {Xn} belong to a type p stable space and are assumed to be independent, but not necessarily identically ...
Volodin A., Adler A.
core  

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

open access: yesMolecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira   +7 more
wiley   +1 more source

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