Results 101 to 110 of about 2,908,473 (291)
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Scaling limits for infinite-server systems in a random environment
Stochastic Systems, 2017 This paper studies the effect of an overdispersed arrival process on the performance of an infinite-server system. In our setup, a random environment is modeled by drawing an arrival rate Λ from a given distribution every Δ time units, yielding an i.i.d.
Mariska Heemskerk +2 more
doaj +1 more source
Branching random walks in random environment and super-Brownian motion in random environment
Annales de l'Institut Henri Poincaré, Probabilités et Statistiques, 2015 We focus on the existence and characterization of the limit for a certain critical branching random walks in time-space random environment in one dimension which was introduced by M. Birnkenr et.al. Each particle performs simple random walk on $\mathbb{Z}$ and branching mechanism depends on the time-space site.
openaire +4 more sources
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Epidemic Random Network Simulations in a Distributed Computing Environment
Abstract and Applied Analysis, 2013 We discuss a computational system following the paradigm of distributed computing, which will allow us to simulate the epidemic propagation in random networks with large number of nodes up to one million.
J. Villanueva-Oller +3 more
doaj +1 more source
Random regression models for detection of gene by environment interaction
Genetics Selection Evolution, 2007 Two random regression models, where the effect of a putative QTL was regressed on an environmental gradient, are described. The first model estimates the correlation between intercept and slope of the random regression, while the other model restricts ...
Meuwissen Theo HE +2 more
doaj +1 more source
Slow movement of random walk in random environment on a regular tree [PDF]
, 2006 We consider a recurrent random walk in random environment on a regular tree. Under suitable general assumptions upon the distribution of the environment, we show that the walk exhibits an unusual slow movement: the order of magnitude of the walk in the ...
Hu, Yueyun, Shi, Zhan
core +5 more sources
Electronic Journal of Probability, 2008 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Merkl, Franz, Rolles, Silke
openaire +2 more sources
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source