Results 51 to 60 of about 360,197 (329)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Assessing Predictability of Marine Heatwaves With Random Forests

Geophysical Research Letters, 2022
Marine heatwaves (MHWs) have increased in frequency and duration over the last century and are expected to intensify in the future. Such events have become an increasing threat for marine ecosystems and subsequently the economies and populations that ...
K. Giamalaki, C. Beaulieu, J. X. Prochaska   +2 more
doaj   +1 more source

Estimation of Vegetation Indices With Random Kernel Forests

IEEE Access, 2023
Vegetation indexes help perform precision farming because they provide useful information regarding moisture, nutrient content, and crop health. Primary sources of those indexes are satellites and unmanned aerial vehicles equipped with expensive ...
Dmitry A. Devyatkin
doaj   +1 more source

Reliable ABC model choice via random forests

, 2015
Approximate Bayesian computation (ABC) methods provide an elaborate approach to Bayesian inference on complex models, including model choice. Both theoretical arguments and simulation experiments indicate, however, that model posterior probabilities may ...
Cornuet, Jean-Marie, Estoup, Arnaud, Gautier, Mathieu, Marin, Jean-Michel, Pudlo, Pierre, Robert, Christian P.   +5 more
core   +2 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Temperature impact on the economic growth effect: method development and model performance evaluation with subnational data in China

EPJ Data Science, 2023
Temperature-economic growth relationships are computed to quantify the impact of climate change on the economy. However, model performance and differences of predictions among research complicate the use of climate econometric estimation.
Yu Song, Zhihua Pan, Fei Lun, Buju Long, Siyu Liu, Guolin Han, Jialin Wang, Na Huang, Ziyuan Zhang, Shangqian Ma, Guofeng Sun, Cong Liu   +11 more
doaj   +1 more source

Risk bounds for purely uniformly random forests [PDF]

, 2010
Random forests, introduced by Leo Breiman in 2001, are a very effective statistical method. The complex mechanism of the method makes theoretical analysis difficult.
Genuer, Robin
core   +3 more sources

An AUC-based Permutation Variable Importance Measure for Random Forests [PDF]

, 2012
The random forest (RF) method is a commonly used tool for classification with high dimensional data as well as for ranking candidate predictors based on the so-called random forest variable importance measures (VIMs).
A Estabrooks, AL Boulesteix, AL Boulesteix, Anne-Laure Boulesteix, C Chen, C Liu, C Strobl, Carolin Strobl, F Briggs, G Batista, J Chang, J Van Hulse, J Van Hulse, K Nicodemus, KK Nicodemus, KK Nicodemus, KK Nicodemus, L Breiman, M Calle, M Cummings, M Khalilia, M Kubat, M Pepe, N Japkowicz, R Blagus, Silke Janitza, T Fawcett, T Hothorn, T Hothorn, T Khoshgoftaar, WJ Lin, Y Huang, Y Sun, Y Xie   +33 more
core   +3 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Determining vertical structure of forests in Poland using a semi-automated approach based on ALS data

Ecological Indicators
The vertical structure of the forest is one of the key characteristics of forest management, influencing biodiversity, resource competition, and various ecological processes. Despite its importance, determining the vertical structure of stands over large
Piotr Janiec, Luiza Tymińska-Czabańska, Paweł Hawryło, Michał Woda, Jarosław Socha   +4 more
doaj   +1 more source